آدیپوز تری‌گلیسرید لیپاز

PNPLA2
معین‌کننده‌ها
نام‌های دیگر	PNPLA2, 1110001C14Rik, ATGL, PEDF-R, TTS-2.2, TTS2, iPLA2zeta, FP17548, patatin like phospholipase domain containing 2
شناسه‌های بیرونی	OMIM: 609059 MGI: 1914103 HomoloGene: 10687 GeneCards: PNPLA2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	141,040,656 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• hydrolase activity; • lipoprotein lipase activity; • acylglycerol O-acyltransferase activity; • triglyceride lipase activity;
ترکیبات سلولی	• integral component of membrane; • سیتوزول; • lipid droplet; • پوسته یاخته; • endoplasmic reticulum membrane; • سیتوپلاسم; • membrane; • نوکلئوپلاسم; • endoplasmic reticulum lumen;
فرایند زیستی	• lipid catabolic process; • lipid storage; • دگرگشت; • negative regulation of sequestering of triglyceride; • positive regulation of triglyceride catabolic process; • acylglycerol acyl-chain remodeling; • lipid droplet organization; • سوخت‌وساز لیپید; • triglyceride catabolic process; • lipid homeostasis; • پیرایش پسارونویسی; • cellular lipid catabolic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	57104
	66853
	ENSG00000177666
	ENSMUSG00000025509
	Q96AD5
	Q8BJ56
	NM_020376
	NM_025802، NR_028142 NM_001163689، NM_025802، NR_028142
	XP_006718328، XP_006718329، XP_016873517، XP_024304386 NP_065109، XP_006718328، XP_006718329، XP_016873517، XP_024304386
	NP_080078 NP_001157161، NP_080078
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

آدیپوز تری‌گلیسرید لیپاز (انگلیسی: Adipose triglyceride lipase) یک آنزیم است که در انسان‌ها توسط ژن «PNPLA2» کدگذاری می‌شود.^[۴]^[۵]^[۶]^[۷]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025509 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
↑ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family" (PDF). J Lipid Res. 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181. Archived from the original (PDF) on 21 July 2018. Retrieved 12 July 2018.
↑ Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.
↑ "Entrez Gene: PNPLA2 patatin-like phospholipase domain containing 2".

مشارکت‌کنندگان ویکی‌پدیا. «Adipose triglyceride lipase». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۲ ژوئیه ۲۰۱۸.

پیوند به بیرون

مکان ژنوم PNPLA2 انسانی و صفحهٔ جزئیات ژنی PNPLA2 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

بیشتر بخوانید

Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Villena JA, Roy S, Sarkadi-Nagy E, et al. (2004). "Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis". J. Biol. Chem. 279 (45): 47066–75. doi:10.1074/jbc.M403855200. PMID 15337759.
Jenkins CM, Mancuso DJ, Yan W, et al. (2005). "Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities". J. Biol. Chem. 279 (47): 48968–75. doi:10.1074/jbc.M407841200. PMID 15364929.
Zimmermann R, Strauss JG, Haemmerle G, et al. (2004). "Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase". Science. 306 (5700): 1383–6. doi:10.1126/science.1100747. PMID 15550674.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Smirnova E, Goldberg EB, Makarova KS, et al. (2006). "ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells". EMBO Rep. 7 (1): 106–13. doi:10.1038/sj.embor.7400559. PMC 1369222. PMID 16239926.
Schoenborn V, Heid IM, Vollmert C, et al. (2006). "The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes". Diabetes. 55 (5): 1270–5. doi:10.2337/db05-1498. PMID 16644682.
Lass A, Zimmermann R, Haemmerle G, et al. (2007). "Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome". Cell Metab. 3 (5): 309–19. doi:10.1016/j.cmet.2006.03.005. PMID 16679289.
Mairal A, Langin D, Arner P, Hoffstedt J (2007). "Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity". Diabetologia. 49 (7): 1629–36. doi:10.1007/s00125-006-0272-x. PMID 16752181.
Notari L, Baladron V, Aroca-Aguilar JD, et al. (2007). "Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor". J. Biol. Chem. 281 (49): 38022–37. doi:10.1074/jbc.M600353200. PMID 17032652.
Fischer J, Lefèvre C, Morava E, et al. (2007). "The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy". Nat. Genet. 39 (1): 28–30. doi:10.1038/ng1951. PMID 17187067.
Rydén M, Jocken J, van Harmelen V, et al. (2007). "Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis". Am. J. Physiol. Endocrinol. Metab. 292 (6): E1847–55. doi:10.1152/ajpendo.00040.2007. PMID 17327373.
Jocken JW, Langin D, Smit E, et al. (2007). "Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state". J. Clin. Endocrinol. Metab. 92 (6): 2292–9. doi:10.1210/jc.2006-1318. PMID 17356053.
Steinberg GR, Kemp BE, Watt MJ (2007). "Adipocyte triglyceride lipase expression in human obesity". Am. J. Physiol. Endocrinol. Metab. 293 (4): E958–64. doi:10.1152/ajpendo.00235.2007. PMID 17609260.
Fischer J, Negre-Salvayre A, Salvayre R (2007). "[Neutral lipid storage diseases and ATGL (adipose triglyceride lipase) and CGI-58/ABHD5 (alpha-beta hydrolase domain-containing 5) deficiency: myopathy, ichthyosis, but no obesity]". Med Sci (Paris). 23 (6–7): 575–8. doi:10.1051/medsci/20072367575. PMID 17631826.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025509 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8619474-4] Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[pmid16799181-5] Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family" (PDF). J Lipid Res. 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181. Archived from the original (PDF) on 21 July 2018. Retrieved 12 July 2018.

[pmid19029121-6] Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.

[entrez-7] "Entrez Gene: PNPLA2 patatin-like phospholipase domain containing 2".

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