اینتگرین بتا-۵

ITGB5
معین‌کننده‌ها
نام‌های دیگر	ITGB5, Integrin, beta 5, integrin subunit beta 5
شناسه‌های بیرونی	OMIM: 147561 MGI: 96614 HomoloGene: 20511 GeneCards: ITGB5
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۶ (موش)
پایان	33,769,708 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• virus receptor activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • integrin binding; • signaling receptor activity;
ترکیبات سلولی	• integral component of membrane; • membrane; • focal adhesion; • receptor complex; • پوسته یاخته; • cell surface; • integrin complex; • phagocytic vesicle; • integrin alphav-beta5 complex; • extracellular exosome;
فرایند زیستی	• کشش ماهیچه; • endodermal cell differentiation; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • extracellular matrix organization; • epithelial cell-cell adhesion; • stress fiber assembly; • چسبندگی سلولی; • integrin-mediated signaling pathway; • ورود ویروس; • cell-matrix adhesion; • GO:0022415 viral process; • transforming growth factor beta receptor signaling pathway; • کوچ یاخته; • cell adhesion mediated by integrin;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3693
	16419
	ENSG00000082781
	ENSMUSG00000022817
	P18084
	O70309
	NM_002213، XM_005247436، XM_017006353، NM_001354764، NM_001354765، NM_001354766، XM_047448087، XM_047448088، XM_047448089 XM_006713630، NM_002213، XM_005247436، XM_017006353، NM_001354764، NM_001354765، NM_001354766، XM_047448087، XM_047448088، XM_047448089
	NM_010580، XM_030248983 NM_001145884، NM_010580، XM_030248983
	XP_005247493، XP_006713693، XP_016861842، XP_016861843، XP_016861844، NP_001341693، NP_001341694، NP_001341695 NP_002204، XP_005247493، XP_006713693، XP_016861842، XP_016861843، XP_016861844، NP_001341693، NP_001341694، NP_001341695
	NP_034710، XP_030104843، NP_001391992 NP_001139356، NP_034710، XP_030104843، NP_001391992
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

اینتگرین بتا-۵ (انگلیسی: Integrin beta-5) یک پروتئین است که در انسان توسط ژن «ITGB5» کُدگذاری می‌شود.^[۴]^[۵]

افزایش سطح این پروتئین در بیمارانی که از «پوکی استخوان نوع ۲» (اتوزومال غالب) رنج می‌برند، دیده شده‌است.^[۶]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022817 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. PMID 2211615.
↑ "Entrez Gene: ITGB5 integrin, beta 5".
↑ Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology". Lab Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069.

مشارکت‌کنندگان ویکی‌پدیا. «Integrin, beta 5». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۸ ژانویه ۲۰۱۸.

بیشتر بخوانید

Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.
Smith JW, Vestal DJ, Irwin SV, et al. (1990). "Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin". J. Biol. Chem. 265 (19): 11008–13. PMID 1694173.
Adams JC, Watt FM (1991). "Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes". J. Cell Biol. 115 (3): 829–41. doi:10.1083/jcb.115.3.829. PMC 2289188. PMID 1918165.
Ramaswamy H, Hemler ME (1990). "Cloning, primary structure and properties of a novel human integrin beta subunit". EMBO J. 9 (5): 1561–8. PMC 551850. PMID 2328726.
Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit". Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5354–8. doi:10.1073/pnas.87.14.5354. PMC 54322. PMID 2371275.
Hu DD, Lin EC, Kovach NL, et al. (1995). "A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5". J. Biol. Chem. 270 (44): 26232–8. doi:10.1074/jbc.270.44.26232. PMID 7592829.
Vogel BE, Lee SJ, Hildebrand A, et al. (1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin". J. Cell Biol. 121 (2): 461–8. doi:10.1083/jcb.121.2.461. PMC 2200091. PMID 7682219.
Pasqualini R, Bodorova J, Ye S, Hemler ME (1993). "A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies". J. Cell Sci. 105 (1): 101–11. PMID 7689573.
Lafrenie RM, Wahl LM, Epstein JS, et al. (1996). "HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes". Journal of Immunology. 157 (3): 974–7. PMID 8757599.
Rabb H, Barroso-Vicens E, Adams R, et al. (1997). "Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney". Am. J. Nephrol. 16 (5): 402–8. doi:10.1159/000169032. PMID 8886177.
Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. PMID 9442085.
Memmo LM, McKeown-Longo P (1998). "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin". J. Cell Sci. 111 (4): 425–33. PMID 9443892.
Zhang H, Tan SM, Lu J (1998). "cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing". Biochem. J. 331 (2): 631–7. PMC 1219398. PMID 9531507.
Barillari G, Sgadari C, Palladino C, et al. (1999). "Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin". Journal of Immunology. 163 (4): 1929–35. PMID 10438928.
Carriero MV, Del Vecchio S, Capozzoli M, et al. (1999). "Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer". Cancer Res. 59 (20): 5307–14. PMID 10537314.
Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC 2169340. PMID 10579726.
Cirulli V, Beattie GM, Klier G, et al. (2000). "Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells". J. Cell Biol. 150 (6): 1445–60. doi:10.1083/jcb.150.6.1445. PMC 2150716. PMID 10995448.
Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells". Nat. Cell Biol. 2 (12): 899–905. doi:10.1038/35046549. PMID 11146654.
Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID 11162558.
Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur J Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022817 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2211615-4] McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. PMID 2211615.

[entrez-5] "Entrez Gene: ITGB5 integrin, beta 5".

[pmid_=_24336069-6] Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology". Lab Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069.

[۱]

[۲]

[۳]

[۴]

[۵]

[۶]