تناسین ایکس

TNXB
ساختارهای موجود
PDB	جستجوی یونی‌پروت انسان: PDBe RCSB
فهرست شناسه‌های PDB
	2CUH, 2CUI, 2CUM
معین‌کننده‌ها
نام‌های دیگر	TNXB, EDS3, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS, tenascin XB, EDSCLL, EDSCLL1
شناسه‌های بیرونی	OMIM: 600985 MGI: 1932137 HomoloGene: 49589 GeneCards: TNXB
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۷ (موش)
پایان	34,938,789 bp
هستی‌شناسی ژن
عملکرد ملکولی	• integrin binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • heparin binding; • extracellular matrix structural constituent; • collagen fibril binding;
ترکیبات سلولی	• GO:0005578 بافت‌مانه برون‌یاخته‌ای; • intracellular anatomical structure; • fibrillar collagen trimer; • extracellular exosome; • extracellular space; • extracellular region; • collagen-containing extracellular matrix;
فرایند زیستی	• collagen fibril organization; • collagen metabolic process; • extracellular matrix organization; • چسبندگی سلولی; • elastic fiber assembly; • actin cytoskeleton organization;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7148
	81877
ENSG00000236236; ENSG00000236221; ENSG00000229353; ENSG00000229341; ENSG00000233323;
	ENSG00000231608; ENSG00000206258; ENSG00000168477
	ENSMUSG00000033327
	P22105
	ن/م
	NM_019105، NM_001365276 NM_032470، NM_019105، NM_001365276
	XM_006525185، XM_006525186، XM_006525187، XM_006525189، XM_006525191، XM_036160854، XM_036160855 NM_031176، XM_006525185، XM_006525186، XM_006525187، XM_006525189، XM_006525191، XM_036160854، XM_036160855
	NP_115859، NP_001352205 NP_061978، NP_115859، NP_001352205
	ن/م
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

تناسین ایکس (انگلیسی: Tenascin X) یا «پروتئین شبه هگزابراکیون» یک گلیکوپروتئین است که در انسان توسط ژن «TNXB» کُد می‌شود و در بافت‌های همبند نظیر پوست، مفاصل و عضلات یافت می‌شود.^[۴]

این پروتئین خاصیت ضدچسبندگی دارد (بر خلاف فیبرونکتین) و احتمالاً در جریانِ فرایند بهبود زخم‌ها، در بلوغِ ماتریکس برون‌یاخته‌ای نقش دارد.^[۵]

فقدان تناسین ایکس موجب بروز یکی از انواع نشانگان اهلرز-دنلوس می‌شود که در آن تراکم کلاژن کاهش یافته و رشته‌های اِلاستیکی تکه‌تکه می‌شوند.^[۶]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033327 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tee MK, Thomson AA, Bristow J, Miller WL (July 1995). "Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X". Genomics. 28 (2): 171–8. doi:10.1006/geno.1995.1128. PMID 8530023.
↑ "Entrez Gene: tenascin XB".
↑ Zweers, MC; Schalkwijk, J; Van Kuppevelt, TH; Van Vlijmen-Willems, IM; Bergers, M; Lethias, C; Lamme, EN (2005). "Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components". Cell and Tissue Research. 319 (2): 279–87. doi:10.1007/s00441-004-1011-6. PMID 15558324.

مشارکت‌کنندگان ویکی‌پدیا. «Tenascin X». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۷.

بیشتر بخوانید

Goepel C (2008). "Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with and without pelvic organ prolapse". Acta Histochem. 110 (3): 204–9. doi:10.1016/j.acthis.2007.10.014. PMID 18155129.
Yuan Y, Nymoen DA, Stavnes HT, et al. (2009). "Tenascin-X is a novel diagnostic marker of malignant mesothelioma". Am. J. Surg. Pathol. 33 (11): 1673–82. doi:10.1097/PAS.0b013e3181b6bde3. PMC 2783994. PMID 19738457.
Egging D, van Vlijmen-Willems I, van Tongeren T, et al. (2007). "Wound healing in tenascin-X deficient mice suggests that tenascin-X is involved in matrix maturation rather than matrix deposition". Connect. Tissue Res. 48 (2): 93–8. doi:10.1080/03008200601166160. PMID 17453911.
Egging DF, van Vlijmen-Willems I, Choi J, et al. (2008). "Analysis of obstetric complications and uterine connective tissue in tenascin-X-deficient humans and mice". Cell Tissue Res. 332 (3): 523–32. doi:10.1007/s00441-008-0591-y. PMC 2386751. PMID 18335242.
Kato A, Endo T, Abiko S, et al. (2008). "Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions". Exp. Cell Res. 314 (14): 2661–73. doi:10.1016/j.yexcr.2008.05.019. PMID 18588874.
Bristow J, Carey W, Egging D, Schalkwijk J (2005). "Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome". American Journal of Medical Genetics. 139C (1): 24–30. doi:10.1002/ajmg.c.30071. PMID 16278880.
Fellay J, Ge D, Shianna KV, et al. (2009). McCarthy MI (ed.). "Common genetic variation and the control of HIV-1 in humans". PLoS Genet. 5 (12): e1000791. doi:10.1371/journal.pgen.1000791. PMC 2791220. PMID 20041166.
Kamatani Y, Matsuda K, Ohishi T, et al. (2008). "Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population". J. Hum. Genet. 53 (1): 64–73. doi:10.1007/s10038-007-0219-1. PMID 18058064.
Valdes AM, Thomson G (2009). "Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1". Diabetes Obes Metab. 11. Suppl 1: 46–52. doi:10.1111/j.1463-1326.2008.01002.x. PMC 2755069. PMID 19143814.
Yu CY (1998). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631.
Endo T, Ariga H, Matsumoto K (2009). "Truncated form of tenascin-X, XB-S, interacts with mitotic motor kinesin Eg5". Mol. Cell. Biochem. 320 (1–2): 53–66. doi:10.1007/s11010-008-9898-y. PMID 18679583.
Sovio U, Bennett AJ, Millwood IY, et al. (2009). Gibson G (ed.). "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966". PLoS Genet. 5 (3): e1000409. doi:10.1371/journal.pgen.1000409. PMC 2646138. PMID 19266077.
Araújo VC, Furuse C, Cury PR, et al. (2008). "Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma". Appl. Immunohistochem. Mol. Morphol. 16 (1): 48–53. doi:10.1097/PAI.0b013e31802eff1c. PMID 18091320.
Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951.
Barcellos LF, May SL, Ramsay PP, et al. (2009). Roopenian DC (ed.). "High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions". PLoS Genet. 5 (10): e1000696. doi:10.1371/journal.pgen.1000696. PMC 2758598. PMID 19851445.
McKinnon E, Morahan G, Nolan D, et al. (2009). "Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach". Diabetes Obes Metab. 11 (Suppl 1): 92–100. doi:10.1111/j.1463-1326.2008.01009.x. PMC 2755510. PMID 19143821.
Chapuis J, Hot D, Hansmannel F, et al. (2009). "Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease". Mol. Psychiatry. 14 (11): 1004–16. doi:10.1038/mp.2009.10. PMC 2860783. PMID 19204726.
Vignal C, Bansal AT, Balding DJ, et al. (2009). "Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci". Arthritis Rheum. 60 (1): 53–62. doi:10.1002/art.24138. PMID 19116923.
Buysschaert ID, Grulois V, Eloy P, et al. (2010). "Genetic evidence for a role of IL33 in nasal polyposis". Allergy. 65 (5): 616–22. doi:10.1111/j.1398-9995.2009.02227.x. PMID 19860791.
Gudbjartsson DF, Bjornsdottir US, Halapi E, et al. (2009). "Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction". Nat. Genet. 41 (3): 342–7. doi:10.1038/ng.323. PMID 19198610.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033327 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530023-4] Tee MK, Thomson AA, Bristow J, Miller WL (July 1995). "Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X". Genomics. 28 (2): 171–8. doi:10.1006/geno.1995.1128. PMID 8530023.

[entrez-5] "Entrez Gene: tenascin XB".

[6] Zweers, MC; Schalkwijk, J; Van Kuppevelt, TH; Van Vlijmen-Willems, IM; Bergers, M; Lethias, C; Lamme, EN (2005). "Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components". Cell and Tissue Research. 319 (2): 279–87. doi:10.1007/s00441-004-1011-6. PMID 15558324.

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