سایکلین ئی۱

CCNE1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1W98
معین‌کننده‌ها
نام‌های دیگر	CCNE1, CCNE, pcyclin E1
شناسه‌های بیرونی	OMIM: 123837 MGI: 88316 HomoloGene: 14452 GeneCards: CCNE1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	37,806,959 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001105 transcription coactivator activity; • kinase activity; • cyclin-dependent protein serine/threonine kinase regulator activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • androgen receptor binding; • protein kinase binding; • cyclin-dependent protein serine/threonine kinase activity; • protein kinase activity;
ترکیبات سلولی	• سیتوزول; • cyclin-dependent protein kinase holoenzyme complex; • نوکلئوپلاسم; • هسته یاخته; • cyclin E1-CDK2 complex; • سیتوپلاسم; • میان‌تن;
فرایند زیستی	• androgen receptor signaling pathway; • مسیر پیام‌رسانی وینت; • regulation of transcription involved in G1/S transition of mitotic cell cycle; • regulation of cell cycle; • تقسیم یاخته; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • protein phosphorylation; • DNA replication initiation; • چرخه یاخته‌ای; • regulation of protein kinase activity; • GO:1901227 negative regulation of transcription by RNA polymerase II; • telomere maintenance; • homologous chromosome pairing at meiosis; • GO:0051178 chromosome organization involved in meiotic cell cycle; • G1/S transition of mitotic cell cycle; • regulation of cyclin-dependent protein serine/threonine kinase activity; • GO:0007067 رشتمان; • regulation of mitotic nuclear division; • positive regulation of cell population proliferation; • positive regulation of cell cycle; • positive regulation of G1/S transition of mitotic cell cycle; • GO:0007090 mitotic cell cycle phase transition;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	898
	12447
	ENSG00000105173
	ENSMUSG00000002068
	P24864
	Q61457
	NM_057182، XM_011527440، NM_001322259، NM_001322261، NM_001322262، XM_047439606 NM_001238، NM_057182، XM_011527440، NM_001322259، NM_001322261، NM_001322262، XM_047439606
	NM_007633
	NP_001309188، NP_001309190، NP_001309191، XP_011525742 NP_001229، NP_001309188، NP_001309190، NP_001309191، XP_011525742; NP_001309190.1 NP_001309188.1، NP_001309190.1
	NP_031659
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

سایکلین ئی۱ (انگلیسی: Cyclin E1) یک پروتئین است که در انسان توسط ژن «CCNE1» بر روی بازوی بلند کروموزوم ۱۹ کُدگذاری می‌شود.^[۴]

این پروتئین در چرخه سلول و میتوز و سرطان‌زایی نقش دارد. دو زیرگونه ساختمانی از این پروتئین وجود دارد اما اطلاعات دقیقی از پیرایش دگرسان آن در دسترس نیست.^[۵]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002068 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lew DJ, Dulić V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.
↑ "Entrez Gene: CCNE1 cyclin E1".

برای مطالعهٔ بیشتر

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Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M, Roberts JM (1991). "Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family". Cell. 66 (6): 1217–28. doi:10.1016/0092-8674(91)90044-Y. PMID 1833068. S2CID 38910227.
Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet. Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M (1995). "Human cyclin E, a nuclear protein essential for the G1-to-S phase transition". Mol. Cell. Biol. 15 (5): 2612–24. doi:10.1128/mcb.15.5.2612. PMC 230491. PMID 7739542.
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Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K (1993). "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1". J. Virol. 67 (12): 7641–7. doi:10.1128/JVI.67.12.7641-7647.1993. PMC 238233. PMID 8230483.
Li Y, Graham C, Lacy S, Duncan AM, Whyte P (1994). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E." Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
Xu X, Burke SP (1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. PMID 8617791.
Ohtani K, DeGregori J, Nevins JR (1996). "Regulation of the cyclin E gene by transcription factor E2F1". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12146–50. doi:10.1073/pnas.92.26.12146. PMC 40313. PMID 8618861.
Geng Y, Eaton EN, Picón M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA (1996). "Regulation of cyclin E transcription by E2Fs and retinoblastoma protein". Oncogene. 12 (6): 1173–80. PMID 8649818.
Poon RY, Jiang W, Toyoshima H, Hunter T (1996). "Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage". J. Biol. Chem. 271 (22): 13283–91. doi:10.1074/jbc.271.22.13283. PMID 8662825.
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Li H, Lahti JM, Valentine M, Saito M, Reed SI, Look AT, Kidd VJ (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors". Genomics. 32 (2): 253–9. doi:10.1006/geno.1996.0112. PMID 8833152.
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Sala A, Kundu M, Casella I, Engelhard A, Calabretta B, Grasso L, Paggi MG, Giordano A, Watson RJ, Khalili K, Peschle C (1997). "Activation of human B-MYB by cyclins". Proc. Natl. Acad. Sci. U.S.A. 94 (2): 532–6. Bibcode:1997PNAS...94..532S. doi:10.1073/pnas.94.2.532. PMC 19547. PMID 9012818.
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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002068 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1833066-4] Lew DJ, Dulić V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.

[entrez-5] "Entrez Gene: CCNE1 cyclin E1".

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