کیناز ۱ وابسته به فسفواینوزیتید

PDPK1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1H1W, 1OKY, 1OKZ, 1UU3, 1UU7, 1UU8, 1UU9, 1UVR, 1W1D, 1W1G, 1W1H, 1Z5M, 2BIY, 2PE0, 2PE1, 2PE2, 2R7B, 2VKI, 2XCH, 2XCK, 3H9O, 3HRC, 3HRF, 3ION, 3IOP, 3NAX, 3NAY, 3NUN, 3NUS, 3NUU, 3NUY, 3ORX, 3ORZ, 3OTU, 3PWY, 3QC4, 3QCQ, 3QCS, 3QCX, 3QCY, 3QD0, 3QD3, 3QD4, 3RCJ, 3RWP, 3RWQ, 3SC1, 4A06, 4A07, 4AW0, 4AW1, 4CT1, 4CT2, 4RQV, 4RRV, 4XX9, 5ACK, 5HO7, 5HO8, 5HKM, 5HNG
معین‌کننده‌ها
نام‌های دیگر	PDPK1, PDK1, PDPK2, PRO0461, PDPK2P, Phosphoinositide-dependent kinase-1, 3-phosphoinositide dependent protein kinase 1
شناسه‌های بیرونی	OMIM: 605213 MGI: 1338068 HomoloGene: 37643 GeneCards: PDPK1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۷ (موش)
پایان	24,369,898 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • phospholipase binding; • insulin receptor binding; • 3-phosphoinositide-dependent protein kinase activity; • protein serine/threonine kinase activity; • phospholipase activator activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • ATP binding; • protein kinase binding; • kinase activity;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • cell projection; • membrane; • focal adhesion; • پوسته یاخته; • نوکلئوپلاسم; • پیوند میان‌یاخته‌ای; • هسته یاخته; • پریکاریون; • GO:0097483، GO:0097481 postsynaptic density; • GO:0016023 cytoplasmic vesicle;
فرایند زیستی	• GO:0007243 intracellular signal transduction; • GO:0009373 regulation of transcription, DNA-templated; • extrinsic apoptotic signaling pathway; • negative regulation of protein kinase activity; • فسفرگیری; • T cell costimulation; • stimulatory C-type lectin receptor signaling pathway; • positive regulation of release of sequestered calcium ion into cytosol; • negative regulation of transforming growth factor beta receptor signaling pathway; • hyperosmotic response; • transcription, DNA-templated; • platelet activation; • cellular response to epidermal growth factor stimulus; • Fc-epsilon receptor signaling pathway; • positive regulation of phospholipase activity; • protein phosphorylation; • negative regulation of cardiac muscle cell apoptotic process; • focal adhesion assembly; • negative regulation of toll-like receptor signaling pathway; • GO:0035404 peptidyl-serine phosphorylation; • regulation of endothelial cell migration; • cellular response to insulin stimulus; • protein autophosphorylation; • regulation of mast cell degranulation; • peptidyl-threonine phosphorylation; • type B pancreatic cell development; • T cell receptor signaling pathway; • کوچ یاخته; • actin cytoskeleton organization; • regulation of I-kappaB kinase/NF-kappaB signaling; • calcium-mediated signaling; • GO:1904089 negative regulation of neuron apoptotic process; • cellular response to brain-derived neurotrophic factor stimulus; • epidermal growth factor receptor signaling pathway; • positive regulation of protein localization to plasma membrane; • activation of protein kinase B activity; • positive regulation of blood vessel endothelial cell migration; • positive regulation of angiogenesis; • positive regulation of vascular endothelial cell proliferation; • positive regulation of sprouting angiogenesis; • negative regulation of endothelial cell apoptotic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5170
	18607
	ENSG00000140992
	ENSMUSG00000024122
	O15530
	Q9Z2A0
	NM_002613، NM_031268، XM_011522521، XM_011522523، XM_024450296، XM_047434198، XM_047434199، XM_047434200، XM_047434201، XM_047434202 NM_001261816، NM_002613، NM_031268، XM_011522521، XM_011522523، XM_024450296، XM_047434198، XM_047434199، XM_047434200، XM_047434201، XM_047434202
	NM_001286662، NM_011062، XM_017317320، XM_017317321، XM_017317322، XM_017317324، XM_017317325، XM_017317326، XM_030249574، XM_030249575 NM_001080773، NM_001286662، NM_011062، XM_017317320، XM_017317321، XM_017317322، XM_017317324، XM_017317325، XM_017317326، XM_030249574، XM_030249575
	NP_002604، NP_112558، XP_011520823، XP_011520825، XP_016878760، XP_016878761، XP_016878762، XP_016878763، XP_016878764، XP_016878765، XP_016878766، XP_024306063، XP_024306064 NP_001248745، NP_002604، NP_112558، XP_011520823، XP_011520825، XP_016878760، XP_016878761، XP_016878762، XP_016878763، XP_016878764، XP_016878765، XP_016878766، XP_024306063، XP_024306064
	NP_001273591، NP_035192، XP_017172809، XP_017172810، XP_017172811، XP_017172813، XP_017172814، XP_017172815، XP_030105434، XP_030105435 NP_001074242، NP_001273591، NP_035192، XP_017172809، XP_017172810، XP_017172811، XP_017172813، XP_017172814، XP_017172815، XP_030105434، XP_030105435
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

کیناز ۱ وابسته به فسفواینوزیتید (انگلیسی: Phosphoinositide-dependent kinase-1) یک آنزیم است که در انسان توسط ژن «PDPK1» کُدگذاری می‌شود.^[۴]

این ژن در ایجاد و پیشرفت ملانوما نقش دارد.^[۵]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024122 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PDPK1".
↑ Scortegagna M, Ruller C, Feng Y, Lazova R, Kluger H, Li JL, De SK, Rickert R, Pellecchia M, Bosenberg M, Ronai ZA (2014). "Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma". Oncogene. 33 (34): 4330–9. doi:10.1038/onc.2013.383. PMC 3955742. PMID 24037523.

مشارکت‌کنندگان ویکی‌پدیا. «Phosphoinositide-dependent kinase-1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر

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پیوند به بیرون

3-phosphoinositide-dependent protein kinase در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024122 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: PDPK1".

[5] Scortegagna M, Ruller C, Feng Y, Lazova R, Kluger H, Li JL, De SK, Rickert R, Pellecchia M, Bosenberg M, Ronai ZA (2014). "Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma". Oncogene. 33 (34): 4330–9. doi:10.1038/onc.2013.383. PMC 3955742. PMID 24037523.

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[۴]

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آنزیم‌ها
فعالیت	جایگاه فعال جایگاه اتصال سه‌گانه کاتالیزگر Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme کوآنزیم کوفاکتور کاتالیز آنزیم
قواعد	دگرریختاری Cooperativity بازدارنده آنزیم فعال‌کننده آنزیم
دسته‌بندی	عدد گروه آنزیم ابرخانواده آنزیم خانواده آنزیم فهرست آنزیم‌ها
سینتیک	سینتیک میکائلیس–منتن طرح ادی هوفستی طرح لاینویور برک طرح هانس وولف
انواع	ای‌سی۱ اکسیدوردوکتازها (فهرست) ای‌سی۲ ترانسفرازها (فهرست) ای‌سی۳ هیدرولازها (فهرست) ای‌سی۴ لیازها (فهرست) ای‌سی۵ ایزومرازها (فهرست) ای‌سی۶ لیگازها (فهرست) ای‌سی۷ ترنسلوکازها (فهرست)