گاما انولاز
گاما انولاز (انگلیسی: Gamma-enolase) که با نام‌های انولاز ۲ و انولاز اختصاصی نرون هم شناخته می‌شود، یک آنزیم است که در انسان توسط ژن «ENO2» کدگذاری می‌شود.[۴][۵]
این آنزیم یکی از ۳ ایزوآنزیمی است که در پستانداران یافت می‌شود.
اهمیت بالینی
ردیابی این آنزیم با استفاده از آنتی‌بادی، جهت شناسایی یاخته‌های عصبی و سلول‌هایی که تمایز نوروآندوکرین دارند، استفاده می‌شود. این آنزیم در «سرطان ریه با منشأ سلول کوچک» هم یافت می‌شود و می‌توان از آن به‌عنوان یک بیومارکر در تشخیص این نوع سرطان بهره برد.[۶]
منابع
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004267 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "ENO2 enolase 2 (gamma, neuronal)". NCBI Entrez Gene database.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) Enolase 2 -131360
- ↑ Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, Vessella RL, Nelson PS (April 2003). "Molecular characterization of prostatic small-cell neuroendocrine carcinoma". Prostate. 55 (1): 55–64. doi:10.1002/pros.10217. PMID 12640661.
- مشارکت‌کنندگان ویکی‌پدیا. «Enolase 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۶ اکتبر ۲۰۱۸.
بیشتر بخوانید
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- Craig SP, Day IN, Thompson RJ, Craig IW (1991). "Localisation of neurone-specific enolase (ENO2) to 12p13". Cytogenet. Cell Genet. 54 (1–2): 71–3. doi:10.1159/000132960. PMID 2249478.
- Oliva D; Barba G; Barbieri G; et al. (1989). "Cloning, expression and sequence homologies of cDNA for human gamma enolase". Gene. 79 (2): 355–60. doi:10.1016/0378-1119(89)90217-5. PMID 2792767.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - McAleese SM; Dunbar B; Fothergill JE; et al. (1989). "Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)". Eur. J. Biochem. 178 (2): 413–7. doi:10.1111/j.1432-1033.1988.tb14465.x. PMID 3208766.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Van Obberghen E; Kamholz J; Bishop JG; et al. (1988). "Human gamma enolase: isolation of a cDNA clone and expression in normal and tumor tissues of human origin". J. Neurosci. Res. 19 (4): 450–6. doi:10.1002/jnr.490190409. PMID 3385803.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Day IN, Allsopp MT, Moore DC, Thompson RJ (1987). "Sequence conservation in the 3'-untranslated regions of neurone-specific enolase, lymphokine and protooncogene mRNAs". FEBS Lett. 222 (1): 139–43. doi:10.1016/0014-5793(87)80207-7. PMID 3653393.
- Haimoto H; Takahashi Y; Koshikawa T; et al. (1985). "Immunohistochemical localization of gamma-enolase in normal human tissues other than nervous and neuroendocrine tissues". Lab. Invest. 52 (3): 257–63. PMID 3974199.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Quan CP; Watanabe S; Vuillier F; et al. (1993). "Purification and partial amino acid sequence of suppressive lymphokine from a CD8+ CD57+ human T hybridoma". Immunology. 78 (2): 205–9. PMC 1421811. PMID 7682534.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Angelov DN; Neiss WF; Gunkel A; et al. (1994). "Axotomy induces intranuclear immunolocalization of neuron-specific enolase in facial and hypoglossal neurons of the rat". J. Neurocytol. 23 (4): 218–33. doi:10.1007/BF01275526. PMID 8035205.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Pechumer H, Bender-Götze C, Ziegler-Heitbrock HW (1994). "Detection of neuron-specific gamma-enolase messenger ribonucleic acid in normal human leukocytes by polymerase chain reaction amplification with nested primers". Lab. Invest. 69 (6): 743–9. PMID 8264236.
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{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Lau L (2002). "Neuroblastoma: a single institution's experience with 128 children and an evaluation of clinical and biological prognostic factors". Pediatric hematology and oncology. 19 (2): 79–89. doi:10.1080/08880010252825669. PMID 11881792.
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{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - O'Dwyer DT; Clifton V; Hall A; et al. (2002). "Pituitary autoantibodies in lymphocytic hypophysitis target both gamma- and alpha-Enolase - a link with pregnancy?". Arch. Physiol. Biochem. 110 (1–2): 94–8. doi:10.1076/apab.110.1.94.897. PMID 11935405.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Chekhonin VP; Zhirkov YA; Belyaeva IA; et al. (2002). "Serum time course of two brain-specific proteins, alpha(1) brain globulin and neuron-specific enolase, in tick-born encephalitis and Lyme disease". Clin. Chim. Acta. 320 (1–2): 117–25. doi:10.1016/S0009-8981(02)00057-8. PMID 11983209.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Nakatsuka S; Nishiu M; Tomita Y; et al. (2005). "Enhanced expression of neuron-specific enolase (NSE) in pyothorax-associated lymphoma (PAL)". Jpn. J. Cancer Res. 93 (4): 411–6. doi:10.1111/j.1349-7006.2002.tb01272.x. PMID 11985791.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Fujiwara H; Arima N; Ohtsubo H; et al. (2002). "Clinical significance of serum neuron-specific enolase in patients with adult T-cell leukemia". Am. J. Hematol. 71 (2): 80–4. doi:10.1002/ajh.10190. PMID 12353304.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Rodríguez-Núñez A; Cid E; Rodríguez-García J; et al. (2003). "Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis". Brain Dev. 25 (2): 102–6. doi:10.1016/S0387-7604(02)00160-2. PMID 12581805.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Muley T; Ebert W; Stieber P; et al. (2003). "Technical performance and diagnostic utility of the new Elecsys neuron-specific enolase enzyme immunoassay". Clin. Chem. Lab. Med. 41 (1): 95–103. doi:10.1515/CCLM.2003.017. PMID 12636057.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help)
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