گیرنده سکرتین

SCTR
معین‌کننده‌ها
نام‌های دیگر	SCTR, SR, secretin receptor
شناسه‌های بیرونی	OMIM: 182098 MGI: 2441720 HomoloGene: 68290 GeneCards: SCTR
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	119,991,266 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• G protein-coupled receptor activity; • transmembrane signaling receptor activity; • signal transducer activity; • secretin receptor activity; • peptide hormone binding; • G protein-coupled peptide receptor activity;
ترکیبات سلولی	• integral component of membrane; • cytoplasmic microtubule; • پوسته یاخته; • membrane;
فرایند زیستی	• cell surface receptor signaling pathway; • GO:0072468 ورارسانی پیام; • G protein-coupled receptor signaling pathway; • brain development; • diet induced thermogenesis; • cellular water homeostasis; • response to nutrient levels; • regulation of appetite; • positive regulation of cAMP-mediated signaling; • regulation of synaptic plasticity;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6344
	319229
	ENSG00000080293
	ENSMUSG00000026387
	P47872
	Q5FWI2
	NM_002980، XM_005263730، XM_011511621، XM_017004670، XM_017004671، XM_017004672، XM_017004673، XR_001738887، XR_001738888، XR_001738889، XM_024453038 XR_922984، NM_002980، XM_005263730، XM_011511621، XM_017004670، XM_017004671، XM_017004672، XM_017004673، XR_001738887، XR_001738888، XR_001738889، XM_024453038
	XM_006529684، XM_006529686، XM_006529688، XM_006529689، XM_006529690، NM_001311077، XM_011248029، XM_011248031، XM_030254873، XM_036165668، XM_036165669، XM_036165670، XM_036165671، XR_004942727 NM_001012322، XM_006529684، XM_006529686، XM_006529688، XM_006529689، XM_006529690، NM_001311077، XM_011248029، XM_011248031، XM_030254873، XM_036165668، XM_036165669، XM_036165670، XM_036165671، XR_004942727
	XP_005263787، XP_011509923، XP_016860159، XP_016860160، XP_016860161، XP_016860162، XP_024308806 NP_002971، XP_005263787، XP_011509923، XP_016860159، XP_016860160، XP_016860161، XP_016860162، XP_024308806
	NP_001298006، XP_006529747، XP_006529749، XP_006529751، XP_006529752، XP_006529753، XP_011246331، XP_011246333، XP_030110733، XP_036021561، XP_036021562، XP_036021563، XP_036021564 NP_001012322، NP_001298006، XP_006529747، XP_006529749، XP_006529751، XP_006529752، XP_006529753، XP_011246331، XP_011246333، XP_030110733، XP_036021561، XP_036021562، XP_036021563، XP_036021564
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده سکرتین انسانی (انگلیسی: Human secretin receptor) یک پروتئین است که در انسان توسط ژن «SCTR» کدگذاری می‌شود.

این پروتئین یک گیرنده جفت‌شونده با پروتئین جی است که به سکرتین اتصال می‌یابد و نخستین عضو از خانوادهٔ گیرنده‌های سکرتین بود که کلون شد.^[۴]

این پروتئین با «پپتید فعال‌کننده آدنیلات سیکلاز هیپوفیز» تعامل پروتئین-پروتئین دارد.^[۵]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026387 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Receptors & Channels. 8 (3–4): 189–200. doi:10.1080/10606820213686. PMID 12529936.
↑ Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT (December 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". The American Journal of Physiology. 263 (6 Pt 1): G901-7. PMID 1335692.

مشارکت‌کنندگان ویکی‌پدیا. «Secretin receptor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۸.

بیشتر بخوانید

Ulrich CD, Holtmann M, Miller LJ (February 1998). "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors". Gastroenterology. 114 (2): 382–97. doi:10.1016/S0016-5085(98)70491-3. PMID 9453500.
Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT (December 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". The American Journal of Physiology. 263 (6 Pt 1): G901-7. PMID 1335692.
Ishihara T, Nakamura S, Kaziro Y, Takahashi T, Takahashi K, Nagata S (July 1991). "Molecular cloning and expression of a cDNA encoding the secretin receptor". The EMBO Journal. 10 (7): 1635–41. PMC 452832. PMID 1646711.
Robberecht P, De Neef P, Waelbroeck M, Camus JC, Scemama JL, Fourmy D, Pradayrol L, Vaysse N, Christophe J (1988). "Secretin receptors in human pancreatic membranes". Pancreas. 3 (5): 529–35. doi:10.1097/00006676-198810000-00004. PMID 3186683.
Chow BK (July 1995). "Molecular cloning and functional characterization of a human secretin receptor". Biochemical and Biophysical Research Communications. 212 (1): 204–11. doi:10.1006/bbrc.1995.1957. PMID 7612008.
Patel DR, Kong Y, Sreedharan SP (March 1995). "Molecular cloning and expression of a human secretin receptor". Molecular Pharmacology. 47 (3): 467–73. PMID 7700244.
Holtmann MH, Hadac EM, Miller LJ (June 1995). "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors". The Journal of Biological Chemistry. 270 (24): 14394–8. doi:10.1074/jbc.270.24.14394. PMID 7782300.
Jiang S, Ulrich C (February 1995). "Molecular cloning and functional expression of a human pancreatic secretin receptor". Biochemical and Biophysical Research Communications. 207 (3): 883–90. doi:10.1006/bbrc.1995.1268. PMID 7864894.
Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (June 1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochemical and Biophysical Research Communications. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245.
Mark HF, Chow BK (October 1995). "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry". Genomics. 29 (3): 817–8. doi:10.1006/geno.1995.9922. PMID 8575789.
Vilardaga JP, di Paolo E, de Neef P, Waelbroeck M, Bollen A, Robberecht P (January 1996). "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin". Biochemical and Biophysical Research Communications. 218 (3): 842–6. doi:10.1006/bbrc.1996.0150. PMID 8579602.
Chow BK (1998). "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor". Receptors & Signal Transduction. 7 (3): 143–50. PMID 9440501.
Shetzline MA, Premont RT, Walker JK, Vigna SR, Caron MG (March 1998). "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor". The Journal of Biological Chemistry. 273 (12): 6756–62. doi:10.1074/jbc.273.12.6756. PMID 9506976.
Ho PK, Fong RS, Kai HS, Lau EH, Ngan ES, Cotton CU, Chow BK (July 1999). "The human secretin receptor gene: genomic organization and promoter characterization". FEBS Letters. 455 (3): 209–14. doi:10.1016/S0014-5793(99)00864-9. PMID 10437774.
Pang RT, Ng SS, Cheng CH, Holtmann MH, Miller LJ, Chow BK (November 1999). "Role of N-linked glycosylation on the function and expression of the human secretin receptor". Endocrinology. 140 (11): 5102–11. doi:10.1210/en.140.11.5102. PMID 10537138.
Chan KY, Pang RT, Chow BK (September 2001). "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor". Endocrinology. 142 (9): 3926–34. doi:10.1210/en.142.9.3926. PMID 11517171.
Pang RT, Lee LT, Ng SS, Yung WH, Chow BK (February 2004). "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene". Molecular Endocrinology. 18 (2): 471–83. doi:10.1210/me.2003-0245. PMID 14645499.

پیوند به بیرون

secretin receptor در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026387 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12529936-4] Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Receptors & Channels. 8 (3–4): 189–200. doi:10.1080/10606820213686. PMID 12529936.

[pmid1335692-5] Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT (December 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". The American Journal of Physiology. 263 (6 Pt 1): G901-7. PMID 1335692.

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