گیرنده مرگ ۴

TNFRSF10A
معین‌کننده‌ها
نام‌های دیگر	TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10a, TNF receptor superfamily member 10a
شناسه‌های بیرونی	OMIM: 603611 MGI: 1341090 HomoloGene: 129806 GeneCards: TNFRSF10A
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	70,021,860 bp
هستی‌شناسی ژن
عملکرد ملکولی	• TRAIL binding; • transcription factor binding; • protease binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • tumor necrosis factor-activated receptor activity; • death receptor activity; • signaling receptor activity;
ترکیبات سلولی	• membrane; • پوسته یاخته; • integral component of plasma membrane; • cell surface; • intracellular anatomical structure; • integral component of membrane;
فرایند زیستی	• activation of NF-kappaB-inducing kinase activity; • TRAIL-activated apoptotic signaling pathway; • multicellular organism development; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • cellular response to mechanical stimulus; • regulation of cell population proliferation; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • regulation of extrinsic apoptotic signaling pathway via death domain receptors; • inflammatory response; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • extrinsic apoptotic signaling pathway via death domain receptors; • GO:0072468 ورارسانی پیام; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • extrinsic apoptotic signaling pathway; • tumor necrosis factor-mediated signaling pathway; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • leukocyte migration; • regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of apoptotic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8797
	21933
	ENSG00000104689
	ENSMUSG00000022074
	O00220
	Q9QZM4
	NM_003844
	XM_036158575 NM_020275، XM_036158575
	NP_003835
	XP_036014468 NP_064671، XP_036014468
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده مرگ ۴ (انگلیسی: Death receptor 4) که با نام‌های DR4، CD261 و گیرندهٔ تریل ۱ نیز شناخته می‌شود، یک گیرندهٔ سطح سلول از ابرخانواده گیرنده‌های فاکتور نکروز تومور است که به پروتئین تریل متصل شده و در خزان یاخته‌ای نقش دارد.^[۴]^[۵]

این گیرنده با DAP3، تعامل پروتئین-پروتئین دارد.^[۶]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022074 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMC 1170170. PMID 9311998.
↑ Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science. 276 (5309): 111–3. doi:10.1126/science.276.5309.111. PMID 9082980.
↑ Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. United States. 2 (6): 493–500. doi:10.1038/88684. ISSN 1529-2908. PMID 11376335. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysummary= و |laysource= (help)

مشارکت‌کنندگان ویکی‌پدیا. «Death receptor 4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۱۹.

برای مطالعهٔ بیشتر

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MacFarlane M, Ahmad M, Srinivasula SM, et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. PMID 9325248.
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Marsters SA, Sheridan JP, Pitti RM, et al. (1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr. Biol. 7 (12): 1003–6. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840.
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Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–32. doi:10.1074/jbc.274.29.20127. PMID 10400625.
Hymowitz SG, Christinger HW, Fuh G, et al. (1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5". Mol. Cell. 4 (4): 563–71. doi:10.1016/S1097-2765(00)80207-5. PMID 10549288.
Gibson SB, Oyer R, Spalding AC, et al. (2000). "Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL". Mol. Cell. Biol. 20 (1): 205–12. doi:10.1128/MCB.20.1.205-212.2000. PMC 85076. PMID 10594023.
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Guan B, Yue P, Lotan R, Sun SY (2002). "Evidence that the human death receptor 4 is regulated by activator protein 1". Oncogene. 21 (20): 3121–9. doi:10.1038/sj.onc.1205430. PMID 12082627.
Söderström TS, Poukkula M, Holmström TH, et al. (2002). "Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8". J. Immunol. 169 (6): 2851–60. doi:10.4049/jimmunol.169.6.2851. PMID 12218097.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022074 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9311998-4] Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMC 1170170. PMID 9311998.

[pmid9082980-5] Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science. 276 (5309): 111–3. doi:10.1126/science.276.5309.111. PMID 9082980.

[pmid11376335-6] Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. United States. 2 (6): 493–500. doi:10.1038/88684. ISSN 1529-2908. PMID 11376335. {{cite journal}}: Cite has empty unknown parameters: |laydate=، |laysummary= و |laysource= (help)

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