BAX

BAX
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4BDU, 1F16, 2G5B, 2K7W, 2LR1, 3PK1, 3PL7, 4BD2, 4BD6, 4BD7, 4BD8, 4UF2, 4ZIE, 4ZIF, 4ZIG, 4ZIH, 4ZII, 4S0O
معین‌کننده‌ها
نام‌های دیگر	BAX, BCL2L4, BCL2 associated X protein, BCL2 associated X, apoptosis regulator
شناسه‌های بیرونی	OMIM: 600040 MGI: 99702 HomoloGene: 7242 GeneCards: BAX
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	45,116,322 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein homodimerization activity; • channel activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • BH3 domain binding; • chaperone binding; • protein heterodimerization activity; • identical protein binding; • lipid binding; • Hsp70 protein binding;
ترکیبات سلولی	• سیتوزول; • nuclear envelope; • membrane; • Bcl-2 family protein complex; • میتوکندری; • هسته یاخته; • mitochondrial permeability transition pore complex; • mitochondrial membranes; • BAX complex; • شبکه آندوپلاسمی; • extracellular exosome; • pore complex; • integral component of membrane; • intracellular anatomical structure; • endoplasmic reticulum membrane; • سیتوپلاسم; • mitochondrial outer membrane; • cell periphery;
فرایند زیستی	• GO:1904089 negative regulation of neuron apoptotic process; • response to ionizing radiation; • germ cell development; • positive regulation of calcium ion transport into cytosol; • glycosphingolipid metabolic process; • B cell apoptotic process; • response to salt stress; • Sertoli cell proliferation; • thymocyte apoptotic process; • T cell homeostatic proliferation; • post-embryonic development; • regulation of mitochondrial membrane permeability involved in apoptotic process; • negative regulation of protein binding; • cellular response to DNA damage stimulus; • regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; • odontogenesis of dentin-containing tooth; • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; • positive regulation of IRE1-mediated unfolded protein response; • blood vessel remodeling; • positive regulation of neuron apoptotic process; • apoptotic process involved in blood vessel morphogenesis; • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; • اسپرماتوژنز; • apoptotic signaling pathway; • تکثیر سلولی; • mitochondrion morphogenesis; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • negative regulation of cell population proliferation; • cellular response to organic substance; • B cell homeostatic proliferation; • limb morphogenesis; • release of matrix enzymes from mitochondria; • extrinsic apoptotic signaling pathway; • kidney development; • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • negative regulation of apoptotic signaling pathway; • myeloid cell homeostasis; • regulation of neuron apoptotic process; • regulation of cysteine-type endopeptidase activity involved in apoptotic process; • endoplasmic reticulum calcium ion homeostasis; • response to wounding; • intrinsic apoptotic signaling pathway by p53 class mediator; • hypothalamus development; • GO:0022415 viral process; • protein homooligomerization; • واکنش به پرتو گاما; • negative regulation of fibroblast proliferation; • positive regulation of intrinsic apoptotic signaling pathway; • response to toxic substance; • B cell negative selection; • GO:1990613 mitochondrial fusion; • neuron apoptotic process; • male gonad development; • positive regulation of B cell apoptotic process; • regulation of protein heterodimerization activity; • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; • cellular response to UV; • sex differentiation; • neuron migration; • B cell homeostasis; • positive regulation of release of sequestered calcium ion into cytosol; • positive regulation of apoptotic process involved in mammary gland involution; • جنین‌شناسی دستگاه عصبی مرکزی; • spermatid differentiation; • development of secondary sexual characteristics; • positive regulation of developmental pigmentation; • retina development in camera-type eye; • response to axon injury; • positive regulation of mitochondrial membrane permeability involved in apoptotic process; • cerebral cortex development; • ovarian follicle development; • لقاح; • ectopic germ cell programmed cell death; • homeostasis of number of cells within a tissue; • positive regulation of release of cytochrome c from mitochondria; • B cell receptor apoptotic signaling pathway; • negative regulation of endoplasmic reticulum calcium ion concentration; • regulation of protein homodimerization activity; • apoptotic process involved in embryonic digit morphogenesis; • leukocyte homeostasis; • positive regulation of apoptotic DNA fragmentation; • mitochondrial fragmentation involved in apoptotic process; • positive regulation of endoplasmic reticulum unfolded protein response; • establishment or maintenance of transmembrane electrochemical gradient; • homeostasis of number of cells; • vagina development; • post-embryonic camera-type eye morphogenesis; • regulation of mammary gland epithelial cell proliferation; • retinal cell programmed cell death; • regulation of cell cycle; • regulation of mitochondrial membrane potential; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • apoptotic mitochondrial changes; • protein complex oligomerization; • regulation of nitrogen utilization; • negative regulation of peptidyl-serine phosphorylation; • positive regulation of apoptotic process; • positive regulation of protein oligomerization; • extrinsic apoptotic signaling pathway via death domain receptors; • release of cytochrome c from mitochondria; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • intrinsic apoptotic signaling pathway; • regulation of apoptotic process; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • intrinsic apoptotic signaling pathway in response to DNA damage; • extrinsic apoptotic signaling pathway in absence of ligand; • transcription initiation from RNA polymerase II promoter; • Unfolded Protein Response; • negative regulation of mitochondrial membrane potential;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	581
	12028
	ENSG00000087088
	ENSMUSG00000003873
	Q07812; Q5ZPJ0
	Q07813
	NM_001291429، NM_001291430، NM_001291431، NM_004324، NM_138761، NM_138762، NM_138763، NM_138764، NR_027882، XM_047439168 NM_001291428، NM_001291429، NM_001291430، NM_001291431، NM_004324، NM_138761، NM_138762، NM_138763، NM_138764، NR_027882، XM_047439168
	XM_006540584، XM_011250780 NM_007527، XM_006540584، XM_011250780
	NP_001278358، NP_001278359، NP_001278360، NP_004315، NP_620116، NP_620118، NP_620119، XP_016882566 NP_001278357، NP_001278358، NP_001278359، NP_001278360، NP_004315، NP_620116، NP_620118، NP_620119، XP_016882566; NP_001278358.1
	XP_006540647، XP_011249082 NP_031553، XP_006540647، XP_011249082
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین ایکس مرتبط با لنفوم ۲ لنفوسیت‌های بی (انگلیسی: Bcl-2-associated X protein) که با نام‌های «BAX تنظیم‌کنندهٔ آپوپتوز» و «پروتئین ۴ شبه لنفوم ۲ لنفوسیت‌های بی» هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «BAX» کُدگذاری می‌شود.

این مولکول، نخستین عضو ایجادکنندهٔ آپوپتوز در خانواده پروتئین Bcl-2 بود که شناخته شد. در حالت عادی، این پروتئین در سیتوزول سلول‌های پستانداران واقع شده‌است. با آغاز آپوپتوز اما، این پروتئین وابسته به غشاء اندامک‌های سلولی شده و به‌ویژه در غشاء میتوکندری جای می‌گیرد.^[۴]^[۵]^[۶]^[۷]^[۸]

اهمیت بالینی

بیان ژن BAX توسط ژن سرکوب‌گر تومور «پی۵۳» تشدید می‌شود و این پروتئین در آپوپتوز وابسته به پی۵۳ نقش مهمی دارد.^[۹]^[۱۰] داروهایی که BAX را فعال می‌کنند، داروهای نویدبخشی در درمان سرطان هستند.^[۱۱] این پروتئین در فرایند کاهش مقاومت دارویی سرطان تخمدان به پاکلیتاکسل دخالت دارد.^[۱۲]

تعاملات شیمیایی

این پروتئین به کلسترول^[۱۳] و کاردیولیپین^[۱۳] تعامل پروتئین-پروتئین دارد.

جستارهای وابسته

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003873 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gross A, Jockel J, Wei MC, Korsmeyer SJ (July 1998). "Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis". EMBO J. 17 (14): 3878–85. doi:10.1093/emboj/17.14.3878. PMC 1170723. PMID 9670005.
↑ Hsu YT, Wolter KG, Youle RJ (April 1997). "Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 3668–72. Bibcode:1997PNAS...94.3668H. doi:10.1073/pnas.94.8.3668. PMC 20498. PMID 9108035.
↑ Nechushtan A, Smith CL, Hsu YT, Youle RJ (May 1999). "Conformation of the Bax C-terminus regulates subcellular location and cell death". EMBO J. 18 (9): 2330–41. doi:10.1093/emboj/18.9.2330. PMC 1171316. PMID 10228148.
↑ Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (January 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID 11161816.
↑ Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ (December 1997). "Movement of Bax from the cytosol to mitochondria during apoptosis". J. Cell Biol. 139 (5): 1281–92. doi:10.1083/jcb.139.5.1281. PMC 2140220. PMID 9382873.
↑ "Entrez Gene: BCL2-associated X protein".
↑ Oltvai ZN, Milliman CL, Korsmeyer SJ (August 1993). "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death". Cell. 74 (4): 609–19. doi:10.1016/0092-8674(93)90509-O. PMID 8358790. S2CID 31151334.
↑ Westphal, D; Kluck, RM; Dewson, G (February 2014). "Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis". Cell Death & Differentiation. 21 (2): 196–205. doi:10.1038/cdd.2013.139. PMC 3890949. PMID 24162660.
↑ Strobel T, Tai YT, Korsmeyer S, Cannistra SA (November 1998). "BAD partly reverses paclitaxel resistance in human ovarian cancer cells". Oncogene. 17 (19): 2419–27. doi:10.1038/sj.onc.1202180. PMID 9824152.
1 2 Mignard, V; Lalier, L; Paris, F; Vallette, FM (29 May 2014). "Bioactive lipids and the control of Bax pro-apoptotic activity". Cell Death & Disease. 5 (5): e1266. doi:10.1038/cddis.2014.226. PMC 4047880. PMID 24874738.

مشارکت‌کنندگان ویکی‌پدیا. «Bcl-2-associated X protein». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اکتبر ۲۰۲۰.

پیوند به بیرون

مکان ژنوم BAX انسانی و صفحهٔ جزئیات ژنی BAX در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: Q07812 (Human Apoptosis regulator BAX) در PDBe-KB.
خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: Q07813 (Mouse Apoptosis regulator BAX) در PDBe-KB.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003873 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9670005-4] Gross A, Jockel J, Wei MC, Korsmeyer SJ (July 1998). "Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis". EMBO J. 17 (14): 3878–85. doi:10.1093/emboj/17.14.3878. PMC 1170723. PMID 9670005.

[pmid9108035-5] Hsu YT, Wolter KG, Youle RJ (April 1997). "Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 3668–72. Bibcode:1997PNAS...94.3668H. doi:10.1073/pnas.94.8.3668. PMC 20498. PMID 9108035.

[pmid10228148-6] Nechushtan A, Smith CL, Hsu YT, Youle RJ (May 1999). "Conformation of the Bax C-terminus regulates subcellular location and cell death". EMBO J. 18 (9): 2330–41. doi:10.1093/emboj/18.9.2330. PMC 1171316. PMID 10228148.

[pmid11161816-7] Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (January 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID 11161816.

[pmid9382873-8] Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ (December 1997). "Movement of Bax from the cytosol to mitochondria during apoptosis". J. Cell Biol. 139 (5): 1281–92. doi:10.1083/jcb.139.5.1281. PMC 2140220. PMID 9382873.

[entrez-9] "Entrez Gene: BCL2-associated X protein".

[Oltvai_1993-10] Oltvai ZN, Milliman CL, Korsmeyer SJ (August 1993). "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death". Cell. 74 (4): 609–19. doi:10.1016/0092-8674(93)90509-O. PMID 8358790. S2CID 31151334.

[pmid24162660-11] Westphal, D; Kluck, RM; Dewson, G (February 2014). "Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis". Cell Death & Differentiation. 21 (2): 196–205. doi:10.1038/cdd.2013.139. PMC 3890949. PMID 24162660.

[pmid9824152-12] Strobel T, Tai YT, Korsmeyer S, Cannistra SA (November 1998). "BAD partly reverses paclitaxel resistance in human ovarian cancer cells". Oncogene. 17 (19): 2419–27. doi:10.1038/sj.onc.1202180. PMID 9824152.

[pmid24874738-13] 1 2 Mignard, V; Lalier, L; Paris, F; Vallette, FM (29 May 2014). "Bioactive lipids and the control of Bax pro-apoptotic activity". Cell Death & Disease. 5 (5): e1266. doi:10.1038/cddis.2014.226. PMC 4047880. PMID 24874738.

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