CBX3

CBX3
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	3TZD, 2L11, 3DM1, 3KUP
معین‌کننده‌ها
نام‌های دیگر	CBX3, HECH, HP1-GAMMA, HP1Hs-gamma, chromobox 3
شناسه‌های بیرونی	OMIM: 604477 MGI: 108515 HomoloGene: 40583 GeneCards: CBX3
موقعیت ژن (موش)
کروموزوم	کروموزوم ۶ (موش)
پایان	51,460,684 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein domain specific binding; • histone methyltransferase binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • identical protein binding; • enzyme binding;
ترکیبات سلولی	• nuclear envelope; • دوک تقسیم; • nuclear inner membrane; • کروماتین; • میان‌پار; • هسته یاخته; • condensed chromosome, centromeric region; • نوکلئوپلاسم; • site of DNA damage; • senescence-associated heterochromatin focus;
فرایند زیستی	• chromatin remodeling; • GO:0009373 regulation of transcription, DNA-templated; • rhythmic process; • transcription, DNA-templated; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of G0 to G1 transition; • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization; • cellular response to DNA damage stimulus; • cellular response to dexamethasone stimulus;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	11335
	12417
	ENSG00000122565
	ENSMUSG00000029836
	Q13185
	P23198
	NM_016587، XM_005249611، XM_047419851 NM_007276، NM_016587، XM_005249611، XM_047419851
	NM_007624، NM_001355002 NM_001037798، NM_007624، NM_001355002
	NP_057671، XP_005249668 NP_009207، NP_057671، XP_005249668
	ن/م
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

هم‌ساخت ۳ پروتئین کروموباکس (انگلیسی: Chromobox protein homolog 3) یک پروتئین است که در انسان توسط ژن «CBX3» کُدگذاری می‌شود.^[۴]^[۵]

این مولکول با پروتئین CBX1^[۶] و CBX5^[۶] تعامل پروتئین-پروتئین دارد.

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029836 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.
↑ "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".
1 2 Nielsen, A L; Oulad-Abdelghani M; Ortiz J A; Remboutsika E; Chambon P; Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697.

مشارکت‌کنندگان ویکی‌پدیا. «CBX3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

Ye Q, Callebaut I, Pezhman A, et al. (1997). "Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR". J. Biol. Chem. 272 (23): 14983–9. doi:10.1074/jbc.272.23.14983. PMID 9169472.
Lessard J, Baban S, Sauvageau G (1998). "Stage-specific expression of polycomb group genes in human bone marrow cells". Blood. 91 (4): 1216–24. PMID 9454751.
Seeler JS, Marchio A, Sitterlin D, et al. (1998). "Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7316–21. Bibcode:1998PNAS...95.7316S. doi:10.1073/pnas.95.13.7316. PMC 22602. PMID 9636146.
Lehming N, Le Saux A, Schüller J, Ptashne M (1998). "Chromatin components as part of a putative transcriptional repressing complex". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7322–6. Bibcode:1998PNAS...95.7322L. doi:10.1073/pnas.95.13.7322. PMC 22604. PMID 9636147.
Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC (1999). "INCENP Centromere and Spindle Targeting: Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1". J. Cell Biol. 143 (7): 1763–74. doi:10.1083/jcb.143.7.1763. PMC 2175214. PMID 9864353.
Ryan RF, Schultz DC, Ayyanathan K, et al. (1999). "KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing". Mol. Cell. Biol. 19 (6): 4366–78. doi:10.1128/mcb.19.6.4366. PMC 104396. PMID 10330177.
Minc E, Allory Y, Worman HJ, et al. (1999). "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells". Chromosoma. 108 (4): 220–34. doi:10.1007/s004120050372. PMID 10460410.
Nielsen AL, Ortiz JA, You J, et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". EMBO J. 18 (22): 6385–95. doi:10.1093/emboj/18.22.6385. PMC 1171701. PMID 10562550.
Koike N, Maita H, Taira T, et al. (2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1): 17–21. doi:10.1016/S0014-5793(00)01105-4. PMID 10664448.
Minc E, Courvalin JC, Buendia B (2001). "HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes". Cytogenet. Cell Genet. 90 (3–4): 279–84. doi:10.1159/000056789. PMID 11124534.
Lachner M, O'Carroll D, Rea S, et al. (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins". Nature. 410 (6824): 116–20. doi:10.1038/35065132. PMID 11242053.
Nielsen AL, Oulad-Abdelghani M, Ortiz JA, et al. (2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. PMID 11336697.
Scholzen T, Endl E, Wohlenberg C, et al. (2002). "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure". J. Pathol. 196 (2): 135–44. doi:10.1002/path.1016. PMID 11793364.
Vassallo MF, Tanese N (2002). "Isoform-specific interaction of HP1 with human TAFII130". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5919–24. Bibcode:2002PNAS...99.5919V. doi:10.1073/pnas.092025499. PMC 122877. PMID 11959914.
Ogawa H, Ishiguro K, Gaubatz S, et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. Bibcode:2002Sci...296.1132O. doi:10.1126/science.1069861. PMID 12004135.
Hwang KK, Worman HJ (2002). "Gene regulation by human orthologs of Drosophila heterochromatin protein 1". Biochem. Biophys. Res. Commun. 293 (4): 1217–22. doi:10.1016/S0006-291X(02)00377-7. PMID 12054505.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kametaka A, Takagi M, Hayakawa T, et al. (2003). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12): 1231–42. doi:10.1046/j.1365-2443.2002.00596.x. PMID 12485163.
Cheutin T, McNairn AJ, Jenuwein T, et al. (2003). "Maintenance of stable heterochromatin domains by dynamic HP1 binding". Science. 299 (5607): 721–5. Bibcode:2003Sci...299..721C. doi:10.1126/science.1078572. PMID 12560555.

پیوند به بیرون

CBX3 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم CBX3 انسانی و صفحهٔ جزئیات ژنی CBX3 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029836 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8663349-4] Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.

[entrez-5] "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".

[pmid11336697-6] 1 2 Nielsen, A L; Oulad-Abdelghani M; Ortiz J A; Remboutsika E; Chambon P; Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697.

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