CXCR4

CXCR4
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4RWS, 2K03, 2K04, 2K05, 3ODU, 3OE0, 3OE6, 3OE8, 3OE9, 2N55
معین‌کننده‌ها
نام‌های دیگر	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, C-X-C motif chemokine receptor 4, WHIMS1
شناسه‌های بیرونی	OMIM: 162643 MGI: 109563 HomoloGene: 20739 GeneCards: CXCR4
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	128,520,030 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0019974 cytokine binding; • coreceptor activity; • virus receptor activity; • signal transducer activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • chemokine receptor activity; • myosin light chain binding; • actin binding; • ubiquitin protein ligase binding; • G protein-coupled receptor activity; • C-X-C chemokine receptor activity; • ubiquitin binding; • C-C chemokine binding; • C-C chemokine receptor activity; • chemokine binding; • C-X-C motif chemokine 12 receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • اندوزوم; • membrane; • cell surface; • پیوند میان‌یاخته‌ای; • cell leading edge; • extracellular exosome; • GO:0016023 cytoplasmic vesicle; • early endosome; • late endosome; • کافنده‌تن; • پوسته یاخته; • external side of plasma membrane; • GO:0009327 protein-containing complex; • هسته یاخته;
فرایند زیستی	• myelin maintenance; • positive regulation of oligodendrocyte differentiation; • response to hypoxia; • positive regulation of cytosolic calcium ion concentration; • chemokine-mediated signaling pathway; • response to virus; • dendritic cell chemotaxis; • cellular response to cytokine stimulus; • کموتاکسی; • inflammatory response; • calcium-mediated signaling; • GO:0072468 ورارسانی پیام; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • GO:0022415 viral process; • fusion of virus membrane with host plasma membrane; • regulation of chemotaxis; • G protein-coupled receptor signaling pathway; • هدایت آسه; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • brain development; • عصب‌زایی; • CXCL12-activated CXCR4 signaling pathway; • cell chemotaxis; • positive regulation of cold-induced thermogenesis; • regulation of cell adhesion; • neuron migration; • epithelial cell development; • neuron recognition; • response to activity; • کوچ یاخته; • telencephalon cell migration; • positive regulation of cell migration; • positive regulation of vascular wound healing; • regulation of programmed cell death; • response to morphine; • endothelial cell differentiation; • positive regulation of neurogenesis; • regulation of viral process; • positive regulation of chemotaxis; • detection of temperature stimulus involved in sensory perception of pain; • detection of mechanical stimulus involved in sensory perception of pain; • regulation of calcium ion transport; • cardiac muscle contraction; • endothelial tube morphogenesis; • positive regulation of dendrite extension; • positive regulation of mesenchymal stem cell migration; • response to ultrasound;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7852
	12767
	ENSG00000121966
	ENSMUSG00000045382
	P61073
	P70658
	NM_001008540، NM_001348056، NM_001348059، NM_001348060، XM_047445802 NM_003467، NM_001008540، NM_001348056، NM_001348059، NM_001348060، XM_047445802
	XM_006529114، NM_001356509، XM_036157035 NM_009911، XM_006529114، NM_001356509، XM_036157035
	NP_003458، NP_001334985، NP_001334988، NP_001334989 NP_001008540، NP_003458، NP_001334985، NP_001334988، NP_001334989
	XP_006529177، NP_001343438، XP_036012928 NP_034041، XP_006529177، NP_001343438، XP_036012928
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

C-X-C chemokine receptor type 4 (انگلیسی: گیرندهٔ نوع ۴ کموکین سی-ایکس-سی) یا «CD184»، یک پروتئین است که انسان توسط ژن «CXCR4» کدگذاری می‌شود.^[۴]^[۵]

این پروتئین نوعی گیرندهٔ آلفا-کموکین اختصاصی برای مولکول پروتئینی SDF1 است که خاصیت کموتاکتیک قوی در جذب لنفوسیت‌ها دارد. SDF1 همچنین در لانه‌گزینی سلول‌های بنیادی خونساز در مغز استخوان نقش مهمی دارد. این پروتئین همچنین بیان ژنی CD20 را در لنفوسیت‌های بی تنظیم می‌کند.^[۶]

CXCR4 یکی از چند گیرندهٔ کموکین است که ویروس اچ‌آی‌وی جهت آلوده‌ساختنِ لنفوسیت‌های تی CD4+ از آنها استفاده می‌کند.

داروهای مسدودکنندهٔ این گیرنده قادرند سلول‌های بنیادی خونساز را به‌تحرک وادارند.

ثابت شده که مواجههٔ طولانی‌مدت با تتراهیدروکانابینول بیان CXCR4 را بر سطح لنفوسیت‌های تی CD4+ و CD8+ در میمون رزوس افزایش می‌دهد.^[۷]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045382 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Moriuchi M, Moriuchi H, Turner W, Fauci AS (November 1997). "Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry". Journal of Immunology. 159 (9): 4322–9. PMID 9379028.
↑ Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (April 1998). "Genomic organization and promoter characterization of human CXCR4 gene". FEBS Letters. 426 (2): 271–8. doi:10.1016/S0014-5793(98)00359-7. PMID 9599023.
↑ Pavlasova G, Borsky M, Seda V, Cerna K, Osickova J, Doubek M, Mayer J, Calogero R, Trbusek M, Pospisilova S, Davids MS, Kipps TJ, Brown JR, Mraz M (August 2016). "Ibrutinib inhibits CD20 up-regulation on CLL B cells mediated by the CXCR4/SDF-1 axis". Blood. 128: 1609–13. doi:10.1182/blood-2016-04-709519. PMID 27480113.
↑ LeCapitaine NJ, Zhang P, Winsauer P, Walker E, Vande Stouwe C, Porretta C, Molina PE (December 2011). "Chronic Δ-9-tetrahydrocannabinol administration increases lymphocyte CXCR4 expression in rhesus macaques". Journal of Neuroimmune Pharmacology. 6 (4): 540–5. doi:10.1007/s11481-011-9277-4. PMC 3181271. PMID 21484257.

مشارکت‌کنندگان ویکی‌پدیا. «CXCR4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۸ آوریل ۲۰۱۸.

برای مطالعهٔ بیشتر

Wilkinson D (September 1996). "Cofactors provide the entry keys. HIV-1". Current Biology. 6 (9): 1051–3. doi:10.1016/S0960-9822(02)70661-1. PMID 8805353.
Broder CC, Dimitrov DS (1996). "HIV and the 7-transmembrane domain receptors". Pathobiology. 64 (4): 171–9. doi:10.1159/000164032. PMID 9031325.
Choe H, Martin KA, Farzan M, Sodroski J, Gerard NP, Gerard C (June 1998). "Structural interactions between chemokine receptors, gp120 Env and CD4". Seminars in Immunology. 10 (3): 249–57. doi:10.1006/smim.1998.0127. PMID 9653051.
Freedman BD, Liu QH, Del Corno M, Collman RG (2003). "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages". Immunologic Research. 27 (2–3): 261–76. doi:10.1385/IR:27:2-3:261. PMID 12857973.
Esté JA (September 2003). "Virus entry as a target for anti-HIV intervention". Current Medicinal Chemistry. 10 (17): 1617–32. doi:10.2174/0929867033457098. PMID 12871111.
Gallo SA, Finnegan CM, Viard M, Raviv Y, Dimitrov A, Rawat SS, Puri A, Durell S, Blumenthal R (July 2003). "The HIV Env-mediated fusion reaction". Biochimica et Biophysica Acta. 1614 (1): 36–50. doi:10.1016/S0005-2736(03)00161-5. PMID 12873764.
Zaitseva M, Peden K, Golding H (July 2003). "HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors". Biochimica et Biophysica Acta. 1614 (1): 51–61. doi:10.1016/S0005-2736(03)00162-7. PMID 12873765.
Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (November 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte Biology. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.
Yi Y, Lee C, Liu QH, Freedman BD, Collman RG (2004). "Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis". Journal of Neurovirology. 10. 10 Suppl 1: 91–6. doi:10.1080/753312758. PMID 14982745.
Seibert C, Sakmar TP (2004). "Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs". Current Pharmaceutical Design. 10 (17): 2041–62. doi:10.2174/1381612043384312. PMID 15279544.
Perfettini JL, Castedo M, Roumier T, Andreau K, Nardacci R, Piacentini M, Kroemer G (August 2005). "Mechanisms of apoptosis induction by the HIV-1 envelope". Cell Death and Differentiation. 12. 12 Suppl 1: 916–23. doi:10.1038/sj.cdd.4401584. PMID 15719026.
King JE, Eugenin EA, Buckner CM, Berman JW (April 2006). "HIV tat and neurotoxicity". Microbes and Infection / Institut Pasteur. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.
Kryczek I, Wei S, Keller E, Liu R, Zou W (March 2007). "Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis". American Journal of Physiology. Cell Physiology. 292 (3): C987-95. doi:10.1152/ajpcell.00406.2006. PMID 16943240.
Arya M, Ahmed H, Silhi N, Williamson M, Patel HR (2007). "Clinical importance and therapeutic implications of the pivotal CXCL12-CXCR4 (chemokine ligand-receptor) interaction in cancer cell migration". Tumour Biology. 28 (3): 123–31. doi:10.1159/000102979. PMID 17510563.
Grange JM (December 1979). "Tuberculosis: the changing tubercle". British Journal of Hospital Medicine. 22 (6): 540–8. PMID 118789.
Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609.
Lu ZH, Wang ZX, Horuk R, Hesselgesser J, Lou YC, Hadley TJ, Peiper SC (November 1995). "The promiscuous chemokine binding profile of the Duffy antigen/receptor for chemokines is primarily localized to sequences in the amino-terminal domain". The Journal of Biological Chemistry. 270 (44): 26239–45. doi:10.1074/jbc.270.44.26239. PMID 7592830.
Jazin EE, Yoo H, Blomqvist AG, Yee F, Weng G, Walker MW, Salon J, Larhammar D, Wahlestedt C (September 1993). "A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells". Regulatory Peptides. 47 (3): 247–58. doi:10.1016/0167-0115(93)90392-L. PMID 8234909.
Loetscher M, Geiser T, O'Reilly T, Zwahlen R, Baggiolini M, Moser B (January 1994). "Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes". The Journal of Biological Chemistry. 269 (1): 232–7. PMID 8276799.
Wang J, Liu X, Lu H, Jiang C, Cui X, Yu L, Fu X, Li Q, Wang J (March 2015). "CXCR4(+)CD45(-) BMMNC subpopulation is superior to unfractionated BMMNCs for protection after ischemic stroke in mice". Brain, Behavior, and Immunity. 45: 98–108. doi:10.1016/j.bbi.2014.12.015. PMC 4342301. PMID 25526817.
Wang J, Yu L, Jiang C, Fu X, Liu X, Wang M, Ou C, Cui X, Zhou C, Wang J (January 2015). "Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system". Brain, Behavior, and Immunity. 43: 172–83. doi:10.1016/j.bbi.2014.07.022. PMC 4258426. PMID 25110149.
Federsppiel B, Melhado IG, Duncan AM, Delaney A, Schappert K, Clark-Lewis I, Jirik FR (June 1993). "Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen". Genomics. 16 (3): 707–12. doi:10.1006/geno.1993.1251. PMID 8325644.
Arimont A, Sun S, Smit MJ, Leurs R, de Esch IJ, de Graaf C (2017). "Structural Analysis of Chemokine Receptor-Ligand Interactions". J Med Chem. doi:10.1021/acs.jmedchem.6b01309. PMID 28165741.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045382 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_9379028-4] Moriuchi M, Moriuchi H, Turner W, Fauci AS (November 1997). "Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry". Journal of Immunology. 159 (9): 4322–9. PMID 9379028.

[pmid_9599023-5] Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (April 1998). "Genomic organization and promoter characterization of human CXCR4 gene". FEBS Letters. 426 (2): 271–8. doi:10.1016/S0014-5793(98)00359-7. PMID 9599023.

[6] Pavlasova G, Borsky M, Seda V, Cerna K, Osickova J, Doubek M, Mayer J, Calogero R, Trbusek M, Pospisilova S, Davids MS, Kipps TJ, Brown JR, Mraz M (August 2016). "Ibrutinib inhibits CD20 up-regulation on CLL B cells mediated by the CXCR4/SDF-1 axis". Blood. 128: 1609–13. doi:10.1182/blood-2016-04-709519. PMID 27480113.

[7] LeCapitaine NJ, Zhang P, Winsauer P, Walker E, Vande Stouwe C, Porretta C, Molina PE (December 2011). "Chronic Δ-9-tetrahydrocannabinol administration increases lymphocyte CXCR4 expression in rhesus macaques". Journal of Neuroimmune Pharmacology. 6 (4): 540–5. doi:10.1007/s11481-011-9277-4. PMC 3181271. PMID 21484257.

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