ENTPD1

ENTPD1
معین‌کننده‌ها
نام‌های دیگر	ENTPD1, ATPDase, CD39, NTPDase-1, SPG64, ectonucleoside triphosphate diphosphohydrolase 1
شناسه‌های بیرونی	OMIM: 601752 MGI: 102805 HomoloGene: 20423 GeneCards: ENTPD1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۹ (موش)
پایان	40,730,046 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• nucleotide binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • hydrolase activity; • ATP binding; • nucleoside-diphosphatase activity; • nucleoside-triphosphatase activity;
ترکیبات سلولی	• integral component of membrane; • integral component of plasma membrane; • extracellular exosome; • membrane; • پوسته یاخته;
فرایند زیستی	• چسبندگی سلولی; • انعقاد خون; • nucleobase-containing small molecule catabolic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	953
	12495
	ENSG00000138185
	ENSMUSG00000048120
	P49961
	P55772
	NM_001164178، NM_001164179، NM_001164181، NM_001164182، NM_001164183، NM_001312654، NM_001776، XM_011540370، XM_011540371، XM_011540372، XM_011540373، XM_011540374، XM_011540376، NM_001320916، XM_017016958، XM_017016963، XM_017016964، XM_047426023، XM_047426024، XM_047426025، XM_047426026، XM_047426027، XM_047426028، XM_047426029 NM_001098175، NM_001164178، NM_001164179، NM_001164181، NM_001164182، NM_001164183، NM_001312654، NM_001776، XM_011540370، XM_011540371، XM_011540372، XM_011540373، XM_011540374، XM_011540376، NM_001320916، XM_017016958، XM_017016963، XM_017016964، XM_047426023، XM_047426024، XM_047426025، XM_047426026، XM_047426027، XM_047426028، XM_047426029
	XM_006526618، XM_006526619، XM_006526620، NM_001304721، XM_017318047 NM_009848، XM_006526618، XM_006526619، XM_006526620، NM_001304721، XM_017318047
	NP_001157650، NP_001157651، NP_001157653، NP_001157654، NP_001157655، NP_001299583، NP_001307845، NP_001767، XP_011538672، XP_011538673، XP_011538674، XP_011538675، XP_011538676، XP_011538678، XP_011538679، XP_016872447، XP_016872448، XP_016872449، XP_016872450، XP_016872451، XP_016872452، XP_016872453 NP_001091645، NP_001157650، NP_001157651، NP_001157653، NP_001157654، NP_001157655، NP_001299583، NP_001307845، NP_001767، XP_011538672، XP_011538673، XP_011538674، XP_011538675، XP_011538676، XP_011538678، XP_011538679، XP_016872447، XP_016872448، XP_016872449، XP_016872450، XP_016872451، XP_016872452، XP_016872453
	NP_033978، XP_006526681، XP_006526682، XP_006526683، XP_017173536 NP_001291650، NP_033978، XP_006526681، XP_006526682، XP_006526683، XP_017173536
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

اِکتونوکلئوزید تری‌فسفات دی‌فسفوهیدرولاز ۱ (انگلیسی: Ectonucleoside triphosphate diphosphohydrolase-1) که با نام «CD39» هم شناخته می‌شود، یک آنزیم سطح سلولی است که بخش کاتالیتیک آن، خارج از سلول قرار می‌گیرد.^[۴]^[۵]^[۶]

این آنزیم یک «اِکتونوکلئوتیداز» است که هیدرولیز باقیمانده‌های گاما-فسفات و بتا-فسفات را در مشتقات مونوفسفونوکلئوزید، دی‌فسفونوکلئوزید و تری‌فسفونوکلئوزید کاتالیز می‌کند.^[۷]^[۸] مثلاً آنزیم NTPDase1، آدنوزین تری‌فسفات، آدنوزین دی‌فسفات، اوریدین تری‌فسفات و اوریدین دی‌فسفات را با اثربخشی مشابه هیدرولیز کرده^[۹] و بنابراین قادر است بر روی فعال‌سازی و عملکرد «گیرندهٔ P2» اثر بگذارد.^[۱۰]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048120 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1".
↑ Sévigny J, Levesque FP, Grondin G, Beaudoin AR (Feb 1997). "Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques". Biochimica et Biophysica Acta. 1334 (1): 73–88. doi:10.1016/s0304-4165(96)00079-7. PMID 9042368.
↑ Kaczmarek E, Koziak K, Sévigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC (Dec 1996). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". The Journal of Biological Chemistry. 271 (51): 33116–22. doi:10.1074/jbc.271.51.33116. PMID 8955160.
↑ Robson SC, Sévigny J, Zimmermann H (Jun 2006). "The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance". Purinergic Signalling. 2 (2): 409–30. doi:10.1007/s11302-006-9003-5. PMC 2254478. PMID 18404480.
↑ Yegutkin GG (May 2008). "Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade". Biochimica et Biophysica Acta. 1783 (5): 673–94. doi:10.1016/j.bbamcr.2008.01.024. PMID 18302942.
↑ Kukulski F, Lévesque SA, Lavoie EG, Lecka J, Bigonnesse F, Knowles AF, Robson SC, Kirley TL, Sévigny J (Jun 2005). "Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8". Purinergic Signalling. 1 (2): 193–204. doi:10.1007/s11302-005-6217-x. PMC 2096530. PMID 18404504.
↑ Kukulski F, Lévesque SA, Sévigny J (2011-01-01). "Impact of ectoenzymes on p2 and p1 receptor signaling". Advances in Pharmacology. 61: 263–99. doi:10.1016/B978-0-12-385526-8.00009-6. PMID 21586362.

مشارکت‌کنندگان ویکی‌پدیا. «ENTPD1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۰ دسامبر ۲۰۱۷.

بیشتر بخوانید

Maliszewski CR, Delespesse GJ, Schoenborn MA, Armitage RJ, Fanslow WC, Nakajima T, Baker E, Sutherland GR, Poindexter K, Birks C (Oct 1994). "The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization". Journal of Immunology. 153 (8): 3574–83. PMID 7930580.
Christoforidis S, Papamarcaki T, Galaris D, Kellner R, Tsolas O (Nov 1995). "Purification and properties of human placental ATP diphosphohydrolase". European Journal of Biochemistry / FEBS. 234 (1): 66–74. doi:10.1111/j.1432-1033.1995.066_c.x. PMID 8529670.
Wang TF, Guidotti G (Apr 1996). "CD39 is an ecto-(Ca2+,Mg2+)-apyrase". The Journal of Biological Chemistry. 271 (17): 9898–901. doi:10.1074/jbc.271.17.9898. PMID 8626624.
Kaczmarek E, Koziak K, Sévigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC (Dec 1996). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". The Journal of Biological Chemistry. 271 (51): 33116–22. doi:10.1074/jbc.271.51.33116. PMID 8955160.
Robson SC, Kaczmarek E, Siegel JB, Candinas D, Koziak K, Millan M, Hancock WW, Bach FH (Jan 1997). "Loss of ATP diphosphohydrolase activity with endothelial cell activation". The Journal of Experimental Medicine. 185 (1): 153–63. doi:10.1084/jem.185.1.153. PMC 2196106. PMID 8996251.
Gray IC, Fallowfield J, Ford S, Nobile C, Volpi EV, Spurr NK (Jul 1997). "An integrated physical and genetic map spanning chromosome band 10q24". Genomics. 43 (1): 85–8. doi:10.1006/geno.1997.4809. PMID 9226376.
Makita K, Shimoyama T, Sakurai Y, Yagi H, Matsumoto M, Narita N, Sakamoto Y, Saito S, Ikeda Y, Suzuki M, Titani K, Fujimura Y (Oct 1998). "Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation". International Journal of Hematology. 68 (3): 297–310. doi:10.1016/S0925-5710(98)00080-2. PMID 9846014.
Matsumoto M, Sakurai Y, Kokubo T, Yagi H, Makita K, Matsui T, Titani K, Fujimura Y, Narita N (Jun 1999). "The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II". FEBS Letters. 453 (3): 335–40. doi:10.1016/S0014-5793(99)00751-6. PMID 10405171.
Kittel A, Kaczmarek E, Sevigny J, Lengyel K, Csizmadia E, Robson SC (Sep 1999). "CD39 as a caveolar-associated ectonucleotidase". Biochemical and Biophysical Research Communications. 262 (3): 596–9. doi:10.1006/bbrc.1999.1254. PMID 10471369.
Koziak K, Kaczmarek E, Kittel A, Sévigny J, Blusztajn JK, Schulte Am Esch J, Imai M, Guckelberger O, Goepfert C, Qawi I, Robson SC (Jan 2000). "Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae". The Journal of Biological Chemistry. 275 (3): 2057–62. doi:10.1074/jbc.275.3.2057. PMID 10636909.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Goepfert C, Imai M, Brouard S, Csizmadia E, Kaczmarek E, Robson SC (Jul 2000). "CD39 modulates endothelial cell activation and apoptosis". Molecular Medicine. 6 (7): 591–603. PMC 1949966. PMID 10997340.
Kittel A, Garrido M, Varga G (Apr 2002). "Localization of NTPDase1/CD39 in normal and transformed human pancreas". The Journal of Histochemistry and Cytochemistry. 50 (4): 549–56. doi:10.1177/002215540205000412. PMID 11897808.
Kaneider NC, Egger P, Dunzendorfer S, Noris P, Balduini CL, Gritti D, Ricevuti G, Wiedermann CJ (Jun 2002). "Reversal of thrombin-induced deactivation of CD39/ATPDase in endothelial cells by HMG-CoA reductase inhibition: effects on Rho-GTPase and adenosine nucleotide metabolism". Arteriosclerosis, Thrombosis, and Vascular Biology. 22 (6): 894–900. doi:10.1161/01.ATV.0000018305.95943.F7. PMID 12067895.
Drosopoulos JH (Oct 2002). "Roles of Asp54 and Asp213 in Ca2+ utilization by soluble human CD39/ecto-nucleotidase". Archives of Biochemistry and Biophysics. 406 (1): 85–95. doi:10.1016/S0003-9861(02)00414-9. PMID 12234494.
Krötz F, Sohn HY, Keller M, Gloe T, Bolz SS, Becker BF, Pohl U (Dec 2002). "Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase". Arteriosclerosis, Thrombosis, and Vascular Biology. 22 (12): 2003–9. doi:10.1161/01.ATV.0000043454.08172.51. PMID 12482826.
Rossatto ER, da Silva LB, Pereira GS, Bonan CD, Battastini AM, Ribeiro JP, Sarkis JJ (Feb 2003). "ATP diphosphohydrolase in human platelets from patients with coronary arteries heart disease". Platelets. 14 (1): 47–52. doi:10.1080/0953710021000062923. PMID 12623446.
Sørensen CE, Amstrup J, Rasmussen HN, Ankorina-Stark I, Novak I (Sep 2003). "Rat pancreas secretes particulate ecto-nucleotidase CD39". The Journal of Physiology. 551 (Pt 3): 881–92. doi:10.1113/jphysiol.2003.049411. PMC 2343304. PMID 12832497.
Sévigny J, Sundberg C, Braun N, Guckelberger O, Csizmadia E, Qawi I, Imai M, Zimmermann H, Robson SC (Apr 2002). "Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation". Blood. 99 (8): 2801–9. doi:10.1182/blood.v99.8.2801. PMID 11929769.

پیوند به بیرون

ENTPD1 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048120 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Entrez Gene: ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1".

[5] Sévigny J, Levesque FP, Grondin G, Beaudoin AR (Feb 1997). "Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques". Biochimica et Biophysica Acta. 1334 (1): 73–88. doi:10.1016/s0304-4165(96)00079-7. PMID 9042368.

[6] Kaczmarek E, Koziak K, Sévigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC (Dec 1996). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". The Journal of Biological Chemistry. 271 (51): 33116–22. doi:10.1074/jbc.271.51.33116. PMID 8955160.

[7] Robson SC, Sévigny J, Zimmermann H (Jun 2006). "The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance". Purinergic Signalling. 2 (2): 409–30. doi:10.1007/s11302-006-9003-5. PMC 2254478. PMID 18404480.

[8] Yegutkin GG (May 2008). "Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade". Biochimica et Biophysica Acta. 1783 (5): 673–94. doi:10.1016/j.bbamcr.2008.01.024. PMID 18302942.

[9] Kukulski F, Lévesque SA, Lavoie EG, Lecka J, Bigonnesse F, Knowles AF, Robson SC, Kirley TL, Sévigny J (Jun 2005). "Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8". Purinergic Signalling. 1 (2): 193–204. doi:10.1007/s11302-005-6217-x. PMC 2096530. PMID 18404504.

[10] Kukulski F, Lévesque SA, Sévigny J (2011-01-01). "Impact of ectoenzymes on p2 and p1 receptor signaling". Advances in Pharmacology. 61: 263–99. doi:10.1016/B978-0-12-385526-8.00009-6. PMID 21586362.

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