FBXO5

FBXO5
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2M6N, 4UI9
معین‌کننده‌ها
نام‌های دیگر	FBXO5, EMI1, FBX5, Fbxo31, F-box protein 5
شناسه‌های بیرونی	OMIM: 606013 MGI: 1914391 HomoloGene: 8135 GeneCards: FBXO5
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۰ (موش)
پایان	5,755,600 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• metal ion binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • protein kinase binding; • GO:0090645، GO:0061637 ubiquitin ligase inhibitor activity; • anaphase-promoting complex binding;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • دوک تقسیم; • نوکلئوپلاسم; • اسکلت سلولی; • هسته یاخته; • meiotic spindle;
فرایند زیستی	• vesicle organization; • regulation of meiotic nuclear division; • microtubule polymerization; • negative regulation of meiotic nuclear division; • regulation of transcription involved in G1/S transition of mitotic cell cycle; • تقسیم یاخته; • spindle assembly; • oocyte maturation; • regulation of mitotic cell cycle; • چرخه یاخته‌ای; • spindle assembly involved in female meiosis I; • regulation of mitotic nuclear division; • GO:0060564، GO:1904190 negative regulation of ubiquitin protein ligase activity; • anaphase-promoting complex-dependent catabolic process; • negative regulation of mitotic metaphase/anaphase transition; • regulation of DNA replication; • positive regulation of cell population proliferation; • positive regulation of G2/M transition of mitotic cell cycle; • negative regulation of DNA endoreduplication; • positive regulation of osteoblast differentiation; • negative regulation of ubiquitin-protein transferase activity; • positive regulation of biomineral tissue development; • positive regulation of mesenchymal stem cell migration; • negative regulation of cellular senescence; • negative regulation of response to DNA damage stimulus; • protein ubiquitination; • regulation of mitotic cell cycle phase transition;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	26271
	67141
	ENSG00000112029
	ENSMUSG00000019773
	Q9UKT4
	Q7TSG3
	NM_012177 NM_001142522، NM_012177
	XM_036155959 NM_025995، XM_036155959
	NP_036309 NP_001135994، NP_036309
	XP_036011852 NP_080271، XP_036011852
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

FBXO5 یک پروتئین است که در انسان توسط ژن «FBXO5» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

این مولکول با پروتئین FZR1^[۷]،CDC20^[۷] و SKP1A^[۸] تعامل پروتئین-پروتئین دارد.

اهمیت بالینی

بیان کمپلکس ترکیبی FBXO5/Emi1 در بسیاری از سرطان‌های انسان مشاهده است. در واقع افزایش بیان آن موجب ناپایداری کروموزومی و ایجاد سرطان می‌گردد.^[۹]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019773 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
↑ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
↑ "Entrez Gene: FBXO5 F-box protein 5".
1 2 Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738.
↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
↑ Vaidyanathan S, Cato K, Tang L, Pavey S, Haass NK, Gabrielli BG, Duijf PH (October 2016). "In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis". Oncogene. 35 (41): 5446–5455. doi:10.1038/onc.2016.94. PMID 27065322.

مشارکت‌کنندگان ویکی‌پدیا. «FBXO5». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۳ مارس ۲۰۱۹.

برای مطالعهٔ بیشتر

Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet. Cell Genet. 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603.
Reimann JD, Freed E, Hsu JY, Kramer ER, Peters JM, Jackson PK (2001). "Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex". Cell. 105 (5): 645–55. doi:10.1016/S0092-8674(01)00361-0. PMID 11389834.
Reimann JD, Jackson PK (2002). "Emi1 is required for cytostatic factor arrest in vertebrate eggs". Nature. 416 (6883): 850–4. doi:10.1038/416850a. PMID 11976684.
Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738.
Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng. 22 (4): 380–4. PMID 12703993.
Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK (2003). "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase". Dev. Cell. 4 (6): 813–26. doi:10.1016/S1534-5807(03)00153-9. PMID 12791267.
Moshe Y, Boulaire J, Pagano M, Hershko A (2004). "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome". Proc. Natl. Acad. Sci. U.S.A. 101 (21): 7937–42. doi:10.1073/pnas.0402442101. PMC 419535. PMID 15148369.
Hansen DV, Loktev AV, Ban KH, Jackson PK (2005). "Plk1 Regulates Activation of the Anaphase Promoting Complex by Phosphorylating and Triggering SCFβTrCP-dependent Destruction of the APC Inhibitor Emi1". Mol. Biol. Cell. 15 (12): 5623–34. doi:10.1091/mbc.E04-07-0598. PMC 532041. PMID 15469984.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK (2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1". Cell. 124 (2): 367–80. doi:10.1016/j.cell.2005.10.038. PMID 16439210.
Lehman NL, Verschuren EW, Hsu JY, Cherry AM, Jackson PK (2006). "Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells". Cell Cycle. 5 (14): 1569–73. doi:10.4161/cc.5.14.2925. PMID 16861914.
Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK (2006). "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor". Genes Dev. 20 (17): 2410–20. doi:10.1101/gad.1454006. PMC 1560415. PMID 16921029.
Marangos P, Verschuren EW, Chen R, Jackson PK, Carroll J (2007). "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APCCdh1". J. Cell Biol. 176 (1): 65–75. doi:10.1083/jcb.200607070. PMC 2063628. PMID 17190794.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019773 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10531035-4] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

[pmid10531037-5] Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.

[entrez-6] "Entrez Gene: FBXO5 F-box protein 5".

[pmid11988738-7] 1 2 Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738.

[autogenerated1-8] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

[Vaidyanathan2016-9] Vaidyanathan S, Cato K, Tang L, Pavey S, Haass NK, Gabrielli BG, Duijf PH (October 2016). "In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis". Oncogene. 35 (41): 5446–5455. doi:10.1038/onc.2016.94. PMID 27065322.

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