FUS

FUS
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2LA6, 2LCW, 4FDD, 4FQ3
معین‌کننده‌ها
نام‌های دیگر	FUS, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, FUS RNA binding protein, altFUS
شناسه‌های بیرونی	OMIM: 137070 MGI: 1353633 GeneCards: FUS
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	127,584,873 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• DNA binding; • GO:0001105 transcription coactivator activity; • metal ion binding; • retinoid X receptor binding; • thyroid hormone receptor binding; • myosin V binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • identical protein binding; • nucleic acid binding; • ionotropic glutamate receptor binding; • estrogen receptor binding; • RNA binding; • chromatin binding;
ترکیبات سلولی	• سیتوپلاسم; • پلی‌زوم; • پریکاریون; • dendritic spine; • نوکلئوپلاسم; • soma; • دندریت; • dendritic spine head; • perinuclear region of cytoplasm; • هسته یاخته;
فرایند زیستی	• cellular response to calcium ion; • mRNA splicing, via spliceosome; • GO:0009373 regulation of transcription, DNA-templated; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • پیرایش آران‌ای; • regulation of RNA splicing; • protein homooligomerization; • positive regulation of nucleic acid-templated transcription; • positive regulation of double-strand break repair via homologous recombination;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2521
	233908
	ENSG00000089280
	ENSMUSG00000030795
	P35637
	P56959
	NM_001010850، NM_001170634، NM_001170937، NM_004960، NR_028388، XM_011545781، XM_024450221 XM_011545782، NM_001010850، NM_001170634، NM_001170937، NM_004960، NR_028388، XM_011545781، XM_024450221
	XM_006507760، XM_017322218، NM_001347649 NM_139149، XM_006507760، XM_017322218، NM_001347649
	NP_001164408، NP_004951، XP_005255290، XP_011544083، XP_011544084، XP_024305989 NP_001164105، NP_001164408، NP_004951، XP_005255290، XP_011544083، XP_011544084، XP_024305989
	NP_631888، XP_006507823، XP_017177707 NP_001334578، NP_631888، XP_006507823، XP_017177707
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین FUS/TLS متصل‌شونده به آران‌ای (انگلیسی: RNA-binding protein FUS/TLS) یک پروتئین است که در انسان توسط ژن «FUS» کُدگذاری می‌شود.^[۴]^[۵]^[۶]^[۷]^[۸]^[۹]

بازآرایی ژن FUS در بروز «لیپوسارکومای میکسوئید» و «سارکومای فیبرومیکسوئید با درجهٔ پائین» نقش دارد.

جهش در این ژن در بیماری اسکلروز جانبی آمیوتروفیک (ALS) ارثی هم کشف شده‌است.^[۱۰]^[۱۱] این ژن همچنین در بروز برخی انواع دمانس فرونتوتمپورال (زوال عقل گیجگاهی-پیشانی) هم مؤثر است.^[۱۲]^[۱۳]^[۱۴]^[۱۵]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030795 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Eneroth M, Mandahl N, Heim S, Willén H, Rydholm A, Alberts KA, Mitelman F (Aug 1990). "Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2". Cancer Genet Cytogenet. 48 (1): 101–7. doi:10.1016/0165-4608(90)90222-V. PMID 2372777.
↑ Rabbitts TH, Forster A, Larson R, Nathan P (Sep 1993). "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma". Nat Genet. 4 (2): 175–80. doi:10.1038/ng0693-175. PMID 7503811.
↑ Prasad DD, Ouchida M, Lee L, Rao VN, Reddy ES (December 1994). "TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain". Oncogene. 9 (12): 3717–29. PMID 7970732.
↑ "Entrez Gene: FUS fusion (involved in t(12;16) in malignant liposarcoma)".
↑ Crozat A, Aman P, Mandahl N, Ron D (June 1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". Nature. 363 (6430): 640–4. doi:10.1038/363640a0. PMID 8510758.
↑ Mrózek K, Karakousis CP, Bloomfield CD (April 1993). "Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3". Cancer Res. 53 (7): 1670–5. PMID 8453640.
↑ Kwiatkowski TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH (February 2009). "Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis". Science. 323 (5918): 1205–1208. doi:10.1126/science.1166066. PMID 19251627.
↑ Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE (February 2009). "Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6". Science. 323 (5918): 1208–11. doi:10.1126/science.1165942. PMID 19251628.
↑ Mackenzie IR, Rademakers R, Neumann M (October 2010). "TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia". Lancet Neurol. 9 (10): 995–1007. doi:10.1016/S1474-4422(10)70195-2. PMID 20864052.
↑ Munoz DG, Neumann M, Kusaka H, Yokota O, Ishihara K, Terada S, Kuroda S, Mackenzie IR (November 2009). "FUS pathology in basophilic inclusion body disease". Acta Neuropathol. 118 (5): 617–27. doi:10.1007/s00401-009-0598-9. PMID 19830439.
↑ Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR (November 2009). "A new subtype of frontotemporal lobar degeneration with FUS pathology". Brain. 132 (Pt 11): 2922–31. doi:10.1093/brain/awp214. PMC 2768659. PMID 19674978.
↑ Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IR (November 2009). "Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease". Acta Neuropathol. 118 (5): 605–16. doi:10.1007/s00401-009-0581-5. PMC 2864784. PMID 19669651.

مشارکت‌کنندگان ویکی‌پدیا. «FUS (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ مه ۲۰۱۸.

برای مطالعهٔ بیشتر

Pereira DS, Dorrell C, Ito CY, Gan OI, Murdoch B, Rao VN, Zou JP, Reddy ES, Dick JE (July 1998). "Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8239–44. doi:10.1073/pnas.95.14.8239. PMC 20960. PMID 9653171.
Yi H, Fujimura Y, Ouchida M, Prasad DD, Rao VN, Reddy ES (March 1997). "Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias". Oncogene. 14 (11): 1259–68. doi:10.1038/sj.onc.1201099. PMID 9178886.
Kaplowitz N, Ji C (2007). "Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum". J. Gastroenterol. Hepatol. 21 Suppl 3: S7–9. doi:10.1111/j.1440-1746.2006.04581.x. PMID 16958678.
Panagopoulos I, Mandahl N, Ron D, Höglund M, Nilbert M, Mertens F, Mitelman F, Aman P (1995). "Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation". Cancer Res. 54 (24): 6500–3. PMID 7987849.
Ichikawa H, Shimizu K, Hayashi Y, Ohki M (1994). "An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation". Cancer Res. 54 (11): 2865–8. PMID 8187069.
Aman P, Panagopoulos I, Lassen C, Fioretos T, Mencinger M, Toresson H, Höglund M, Forster A, Rabbitts TH, Ron D, Mandahl N, Mitelman F (1997). "Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS". Genomics. 37 (1): 1–8. doi:10.1006/geno.1996.0513. PMID 8921363.
Zinszner H, Sok J, Immanuel D, Yin Y, Ron D (1997). "TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling". J. Cell Sci. 110 (15): 1741–50. PMID 9264461.
Powers CA, Mathur M, Raaka BM, Ron D, Samuels HH (1998). "TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors". Mol. Endocrinol. 12 (1): 4–18. doi:10.1210/me.12.1.4. PMID 9440806.
Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F (1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838–42. doi:10.1074/jbc.273.9.4838. PMID 9478924.
Zhang D, Paley AJ, Childs G (1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription". J. Biol. Chem. 273 (29): 18086–91. doi:10.1074/jbc.273.29.18086. PMID 9660765.
Yang L, Embree LJ, Tsai S, Hickstein DD (1998). "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing". J. Biol. Chem. 273 (43): 27761–4. doi:10.1074/jbc.273.43.27761. PMID 9774382.
Bertrand P, Akhmedov AT, Delacote F, Durrbach A, Lopez BS (1999). "Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation". Oncogene. 18 (31): 4515–21. doi:10.1038/sj.onc.1203048. PMID 10442642.
Baechtold H, Kuroda M, Sok J, Ron D, Lopez BS, Akhmedov AT (1999). "Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation". J. Biol. Chem. 274 (48): 34337–42. doi:10.1074/jbc.274.48.34337. PMID 10567410.
Yang L, Embree LJ, Hickstein DD (2000). "TLS-ERG Leukemia Fusion Protein Inhibits RNA Splicing Mediated by Serine-Arginine Proteins". Mol. Cell. Biol. 20 (10): 3345–54. doi:10.1128/MCB.20.10.3345-3354.2000. PMC 85627. PMID 10779324.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
Uranishi H, Tetsuka T, Yamashita M, Asamitsu K, Shimizu M, Itoh M, Okamoto T (2001). "Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator". J. Biol. Chem. 276 (16): 13395–401. doi:10.1074/jbc.M011176200. PMID 11278855.
Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, Barber GN (2001). "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR". J. Biol. Chem. 276 (34): 32300–12. doi:10.1074/jbc.M104207200. PMID 11438536.
Lee J, Bedford MT (2002). "PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays". EMBO Rep. 3 (3): 268–73. doi:10.1093/embo-reports/kvf052. PMC 1084016. PMID 11850402.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030795 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_2372777-4] Eneroth M, Mandahl N, Heim S, Willén H, Rydholm A, Alberts KA, Mitelman F (Aug 1990). "Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2". Cancer Genet Cytogenet. 48 (1): 101–7. doi:10.1016/0165-4608(90)90222-V. PMID 2372777.

[pmid_7503811-5] Rabbitts TH, Forster A, Larson R, Nathan P (Sep 1993). "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma". Nat Genet. 4 (2): 175–80. doi:10.1038/ng0693-175. PMID 7503811.

[pmid_7970732-6] Prasad DD, Ouchida M, Lee L, Rao VN, Reddy ES (December 1994). "TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain". Oncogene. 9 (12): 3717–29. PMID 7970732.

[entrez-7] "Entrez Gene: FUS fusion (involved in t(12;16) in malignant liposarcoma)".

[pmid_8510758-8] Crozat A, Aman P, Mandahl N, Ron D (June 1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". Nature. 363 (6430): 640–4. doi:10.1038/363640a0. PMID 8510758.

[pmid_8453640-9] Mrózek K, Karakousis CP, Bloomfield CD (April 1993). "Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3". Cancer Res. 53 (7): 1670–5. PMID 8453640.

[Kwiatkowski_2009-10] Kwiatkowski TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH (February 2009). "Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis". Science. 323 (5918): 1205–1208. doi:10.1126/science.1166066. PMID 19251627.

[pmid_19251628-11] Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE (February 2009). "Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6". Science. 323 (5918): 1208–11. doi:10.1126/science.1165942. PMID 19251628.

[pmid_20864052-12] Mackenzie IR, Rademakers R, Neumann M (October 2010). "TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia". Lancet Neurol. 9 (10): 995–1007. doi:10.1016/S1474-4422(10)70195-2. PMID 20864052.

[pmid_19830439-13] Munoz DG, Neumann M, Kusaka H, Yokota O, Ishihara K, Terada S, Kuroda S, Mackenzie IR (November 2009). "FUS pathology in basophilic inclusion body disease". Acta Neuropathol. 118 (5): 617–27. doi:10.1007/s00401-009-0598-9. PMID 19830439.

[pmid_19674978-14] Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR (November 2009). "A new subtype of frontotemporal lobar degeneration with FUS pathology". Brain. 132 (Pt 11): 2922–31. doi:10.1093/brain/awp214. PMC 2768659. PMID 19674978.

[pmid_19669651-15] Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IR (November 2009). "Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease". Acta Neuropathol. 118 (5): 605–16. doi:10.1007/s00401-009-0581-5. PMC 2864784. PMID 19669651.

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