FZD1

FZD1
معین‌کننده‌ها
نام‌های دیگر	FZD1, frizzled class receptor 1
شناسه‌های بیرونی	OMIM: 603408 MGI: 1196625 HomoloGene: 20750 GeneCards: FZD1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۵ (موش)
پایان	4,808,035 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• PDZ domain binding; • GO:0005110 frizzled binding; • signal transducer activity; • Wnt-protein binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • Wnt-activated receptor activity; • signaling receptor binding; • transmembrane signaling receptor activity; • G protein-coupled receptor activity;
ترکیبات سلولی	• Wnt signalosome; • membrane; • focal adhesion; • پوسته یاخته; • cell surface; • integral component of membrane;
فرایند زیستی	• G protein-coupled receptor signaling pathway; • positive regulation of protein phosphorylation; • پیام‌رسانی اتوکراین; • epithelial cell differentiation; • muscular septum morphogenesis; • ventricular septum morphogenesis; • cell-cell signaling; • membranous septum morphogenesis; • outflow tract morphogenesis; • positive regulation of DNA-binding transcription factor activity; • مسیر پیام‌رسانی وینت; • planar cell polarity pathway involved in neural tube closure; • negative regulation of BMP signaling pathway; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • multicellular organism development; • cell surface receptor signaling pathway; • canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; • canonical Wnt signaling pathway involved in osteoblast differentiation; • hard palate development; • neuron differentiation; • canonical Wnt signaling pathway; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0072468 ورارسانی پیام; • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; • beta-catenin destruction complex disassembly; • Wnt signaling pathway, planar cell polarity pathway; • presynapse assembly; • negative regulation of oxidative stress-induced neuron death; • non-canonical Wnt signaling pathway; • positive regulation of neuron projection development; • negative regulation of canonical Wnt signaling pathway; • regulation of presynapse assembly;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8321
	14362
	ENSG00000157240
	ENSMUSG00000044674
	Q9UP38
	O70421
	NM_003505
	NM_021457
	NP_003496
	NP_067432
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فریزلد ۱ (انگلیسی: Frizzled-1) یک پروتئین است که در انسان توسط ژن «FZD1» کدگذاری می‌شود.^[۴]^[۵]

اعضای خانوادهٔ ژن‌های فریزلد، یک گیرنده جفت‌شونده با پروتئین جی با هفت دومین پروتئینی تراغشایی را کد می‌کنند که همگی پروتئین‌های مسیر سیگنالینگ Wnt هستند.

نسخهٔ‌های رونویسی در بافت‌های گوناگونی از بدن بیان می‌شود.^[۵]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044674 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
1 2 "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)".

مشارکت‌کنندگان ویکی‌پدیا. «FZD1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۷ دسامبر ۲۰۱۸.

برای مطالعهٔ بیشتر

Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA (Oct 1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.
DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (May 2002). "The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor". Naunyn-Schmiedeberg's Archives of Pharmacology. 365 (5): 341–8. doi:10.1007/s00210-002-0540-3. PMID 12012019.
Hering H, Sheng M (Jun 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Letters. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
Zilberberg A, Yaniv A, Gazit A (Apr 2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway". The Journal of Biological Chemistry. 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID 14739301.
Wu J, Klein TJ, Mlodzik M (Jul 2004). "Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity". PLoS Biology. 2 (7): E158. doi:10.1371/journal.pbio.0020158. PMC 449784. PMID 15252441.
Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
Yang L, Yamasaki K, Shirakata Y, Dai X, Tokumaru S, Yahata Y, Tohyama M, Hanakawa Y, Sayama K, Hashimoto K (May 2006). "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes". Journal of Dermatological Science. 42 (2): 111–9. doi:10.1016/j.jdermsci.2005.12.011. PMID 16442268.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044674 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9813155-4] Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.

[entrez-5] 1 2 "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)".

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