FZD9

FZD9
معین‌کننده‌ها
نام‌های دیگر	FZD9, CD349, FZD3, frizzled class receptor 9
شناسه‌های بیرونی	OMIM: 601766 MGI: 1313278 HomoloGene: 2619 GeneCards: FZD9
موقعیت ژن (موش)
کروموزوم	کروموزوم ۵ (موش)
پایان	135,280,084 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein homodimerization activity; • signal transducer activity; • Wnt-protein binding; • protein heterodimerization activity; • transmembrane signaling receptor activity; • G protein-coupled receptor activity; • Wnt-activated receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • membrane; • پوسته یاخته; • cell surface; • perinuclear region of cytoplasm; • filopodium membrane; • endoplasmic reticulum membrane; • دستگاه گلژی; • mitochondrial membranes; • integral component of membrane; • postsynapse; • glutamatergic synapse;
فرایند زیستی	• G protein-coupled receptor signaling pathway; • مسیر پیام‌رسانی وینت; • جنین‌شناسی دستگاه عصبی مرکزی; • multicellular organism development; • cell surface receptor signaling pathway; • learning or memory; • neuroblast proliferation; • B cell differentiation; • GO:0072468 ورارسانی پیام; • استخوان‌سازی; • release of cytochrome c from mitochondria; • positive regulation of bone mineralization; • positive regulation of apoptotic process; • GO:1904089 negative regulation of neuron apoptotic process; • regulation of cytosolic calcium ion concentration; • negative regulation of mitochondrial depolarization; • negative regulation of necroptotic process; • positive regulation of canonical Wnt signaling pathway; • negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; • regulation of skeletal muscle acetylcholine-gated channel clustering; • negative regulation of skeletal muscle acetylcholine-gated channel clustering; • bone regeneration; • positive regulation of neural precursor cell proliferation; • non-canonical Wnt signaling pathway; • canonical Wnt signaling pathway; • postsynapse organization; • regulation of postsynaptic cytosolic calcium ion concentration;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8326
	14371
	ENSG00000188763
	ENSMUSG00000049551
	O00144
	Q9R216
	NM_003508
	NM_010246
	NP_003499
	NP_034376
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فریزلد ۹ (انگلیسی: Frizzled-9) یا CD349 یک پروتئین است که در انسان توسط ژن «FZD9» کدگذاری می‌شود.^[۴]^[۵]^[۶]

اعضای خانوادهٔ ژن‌های فریزلد، یک گیرنده جفت‌شونده با پروتئین جی با هفت دومین پروتئینی تراغشایی را کد می‌کنند که همگی پروتئین‌های مسیر سیگنالینگ Wnt هستند.

فریزلد ۹ بیشتر در مغز، بیضه، چشم و ماهیچه اسکلتی و کلیه بیان می‌شود.^[۶]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049551 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (Mar 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics. 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651.
↑ Wang YK, Spörle R, Paperna T, Schughart K, Francke U (Apr 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics. 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163.
1 2 "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)".

مشارکت‌کنندگان ویکی‌پدیا. «FZD9». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۸ دسامبر ۲۰۱۸.

برای مطالعهٔ بیشتر

Datta DV (May 1977). "Viral hepatitis (Chandigarh study)". The Journal of the Association of Physicians of India. 25 (5): 325–30. PMID 914765.
Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (Jun 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ (Oct 2002). "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling". The Journal of Biological Chemistry. 277 (40): 37479–86. doi:10.1074/jbc.M205658200. PMID 12138115.
Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE (May 2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". The Journal of Biological Chemistry. 280 (20): 19625–34. doi:10.1074/jbc.M409392200. PMID 15705594.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT, Heasley LE, Nemenoff RA (Sep 2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry. 281 (37): 26943–50. doi:10.1074/jbc.M604145200. PMID 16835228.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049551 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9147651-4] Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (Mar 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics. 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651.

[pmid10198163-5] Wang YK, Spörle R, Paperna T, Schughart K, Francke U (Apr 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics. 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163.

[entrez-6] 1 2 "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)".

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