HBEGF

HBEGF
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1XDT, 2M8S
معین‌کننده‌ها
نام‌های دیگر	HBEGF, DTR, DTS, DTSF, HEGFL, heparin binding EGF like growth factor
شناسه‌های بیرونی	OMIM: 126150 MGI: 96070 HomoloGene: 1466 GeneCards: HBEGF
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۸ (موش)
پایان	36,648,858 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• growth factor activity; • heparin binding; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • epidermal growth factor receptor binding;
ترکیبات سلولی	• extracellular region; • endocytic vesicle membrane; • integral component of membrane; • membrane; • cell surface; • پوسته یاخته; • clathrin-coated endocytic vesicle membrane; • integral component of plasma membrane; • extracellular space; • clathrin-coated vesicle membrane;
فرایند زیستی	• positive regulation of keratinocyte migration; • cell chemotaxis; • MAPK cascade; • GO:0072468 ورارسانی پیام; • wound healing, spreading of epidermal cells; • positive regulation of cell migration; • positive regulation of cell growth; • muscle organ development; • positive regulation of smooth muscle cell proliferation; • regulation of heart contraction; • negative regulation of elastin biosynthetic process; • کوچ یاخته; • positive regulation of wound healing; • epidermal growth factor receptor signaling pathway; • ERBB2 signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • regulation of cell motility; • positive regulation of cell population proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling; • negative regulation of epidermal growth factor receptor signaling pathway; • membrane organization;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	1839
	15200
	ENSG00000113070
	ENSMUSG00000024486
	Q99075
	Q06186
	NM_001945
	NM_010415
	NP_001936
	NP_034545
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فاکتور رشد شبه EGF متصل‌شونده به هپارین (انگلیسی: Heparin-binding EGF-like growth factor) که گاهی به‌صورت «HB-EGF» هم نوشته می‌شود، یکی از پروتئین‌های متعلق به خانوادهٔ فاکتور رشد اپیدرمی است که در انسان توسط ژن «HBEGF» کُد می‌شود.

این مولکول توسط ماکروفاژها و مونوسیت‌ها، به‌صورت یک گلیکوپروتئین میتوژنیک و کموتاکتیک متصل‌به غشاء ساخته می‌شود و تمایل اتصالی به هپارین دارد.

این پروتئین در بهبود زخم، هایپرتروفی و تکامل قلب و عملکرد آن نقش دارد.^[۴] نوعِ تراغشایی HB-EGF یک گیرندهٔ انصاری برای سم دیفتری است. هر دو نوعِ HB-EGF در فرایندهای طبیعی فیزیولوژیک و همچنین بیماری‌ها از جمله پیشرفت و گسترش سرطان، هایپرپلازی اعضاء و احشاء و بیماری تصلب شرائین موثرند.^[۵]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024486 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nanba D, Higashiyama S (February 2004). "Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor". Cytokine Growth Factor Rev. 15 (1): 13–9. doi:10.1016/j.cytogfr.2003.10.002. PMID 14746810.
↑ Raab G, Klagsbrun M (December 1997). "Heparin-binding EGF-like growth factor". Biochim. Biophys. Acta. 1333 (3): F179–99. doi:10.1016/S0304-419X(97)00024-3. PMID 9426203.

مشارکت‌کنندگان ویکی‌پدیا. «Heparin-binding EGF-like growth factor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۵ نوامبر ۲۰۱۷.

بیشتر بخوانید

Higashiyama S, Lau K, Besner GE, et al. (1992). "Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein". J. Biol. Chem. 267 (9): 6205–12. PMID 1556128.
Yoshizumi M, Kourembanas S, Temizer DH, et al. (1992). "Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells". J. Biol. Chem. 267 (14): 9467–9. PMID 1577791.
Higashiyama S, Abraham JA, Miller J, et al. (1991). "A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF". Science. 251 (4996): 936–9. doi:10.1126/science.1840698. PMID 1840698.
Iwamoto R, Senoh H, Okada Y, et al. (1991). "An antibody that inhibits the binding of diphtheria toxin to cells revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor". J. Biol. Chem. 266 (30): 20463–9. PMID 1939101.
Hayes H, Kaneda Y, Uchida T, Okada Y (1988). "Regional assignment of the gene for diphtheria toxin sensitivity using subchromosomal fragments in microcell hybrids". Chromosoma. 96 (1): 26–32. doi:10.1007/BF00285879. PMID 3436221.
Bennett KL, Jackson DG, Simon JC, et al. (1995). "CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor". J. Cell Biol. 128 (4): 687–98. doi:10.1083/jcb.128.4.687. PMC 2199889. PMID 7532176.
Pathak BG, Gilbert DJ, Harrison CA, et al. (1995). "Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl)". Genomics. 28 (1): 116–8. doi:10.1006/geno.1995.1116. PMID 7590736.
Mitamura T, Higashiyama S, Taniguchi N, et al. (1995). "Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity". J. Biol. Chem. 270 (3): 1015–9. doi:10.1074/jbc.270.3.1015. PMID 7836353.
Hashimoto K, Higashiyama S, Asada H, et al. (1994). "Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes". J. Biol. Chem. 269 (31): 20060–6. PMID 8051092.
Kobrin MS, Funatomi H, Friess H, et al. (1994). "Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer". Biochem. Biophys. Res. Commun. 202 (3): 1705–9. doi:10.1006/bbrc.1994.2131. PMID 8060360.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Thompson SA, Higashiyama S, Wood K, et al. (1994). "Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin". J. Biol. Chem. 269 (4): 2541–9. PMID 8300582.
Fen Z, Dhadly MS, Yoshizumi M, et al. (1993). "Structural organization and chromosomal assignment of the gene encoding the human heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor". Biochemistry. 32 (31): 7932–8. doi:10.1021/bi00082a014. PMID 8347598.
Elenius K, Paul S, Allison G, et al. (1997). "Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation". EMBO J. 16 (6): 1268–78. doi:10.1093/emboj/16.6.1268. PMC 1169725. PMID 9135143.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Louie GV, Yang W, Bowman ME, Choe S (1998). "Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor". Mol. Cell. 1 (1): 67–78. doi:10.1016/S1097-2765(00)80008-8. PMID 9659904.
Borer JG, Park JM, Atala A, et al. (1999). "Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction". Lab. Invest. 79 (11): 1335–45. PMID 10576204.
Nakamura K, Mitamura T, Takahashi T, et al. (2000). "Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity". J. Biol. Chem. 275 (24): 18284–90. doi:10.1074/jbc.M907971199. PMID 10749879.
Duque JL, Adam RM, Mullen JS, et al. (2001). "Heparin-binding epidermal growth factor-like growth factor is an autocrine mediator of human prostate stromal cell growth in vitro". J. Urol. 165 (1): 284–8. doi:10.1097/00005392-200101000-00080. PMID 11125426.
Lin J, Hutchinson L, Gaston SM, et al. (2001). "BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation". J. Biol. Chem. 276 (32): 30127–32. doi:10.1074/jbc.M010237200. PMID 11340068.

پیوند به بیرون

heparin-binding EGF-like growth factor در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024486 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14746810-4] Nanba D, Higashiyama S (February 2004). "Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor". Cytokine Growth Factor Rev. 15 (1): 13–9. doi:10.1016/j.cytogfr.2003.10.002. PMID 14746810.

[pmid9426203-5] Raab G, Klagsbrun M (December 1997). "Heparin-binding EGF-like growth factor". Biochim. Biophys. Acta. 1333 (3): F179–99. doi:10.1016/S0304-419X(97)00024-3. PMID 9426203.

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