HCK

HCK
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1AD5, 1BU1, 1QCF, 2C0I, 2C0O, 2C0T, 2HCK, 2HK5, 2OI3, 2OJ2, 3HCK, 3NHN, 3RBB, 3REA, 3REB, 3VRY, 3VRZ, 3VS0, 3VS1, 3VS2, 3VS3, 3VS4, 3VS5, 3VS6, 3VS7, 4HCK, 4LUD, 4LUE, 4ORZ, 4U5W, 5HCK
معین‌کننده‌ها
نام‌های دیگر	HCK, JTK9, p59Hck, p61Hck, HCK proto-oncogene, Src family tyrosine kinase
شناسه‌های بیرونی	OMIM: 142370 MGI: 96052 HomoloGene: 20489 GeneCards: HCK
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	152,993,361 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • non-membrane spanning protein tyrosine kinase activity; • kinase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • signaling receptor binding; • ATP binding; • protein tyrosine kinase activity; • phosphotyrosine residue binding;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • دستگاه گلژی; • cell projection; • membrane; • focal adhesion; • extrinsic component of cytoplasmic side of plasma membrane; • transport vesicle; • پیوند میان‌یاخته‌ای; • ریزرشته; • حفره غشایی; • کافنده‌تن; • اسکلت سلولی; • GO:0016023 cytoplasmic vesicle; • هسته یاخته; • نوکلئوپلاسم; • پوسته یاخته;
فرایند زیستی	• دگرگونی یاخته‌; • leukocyte migration involved in immune response; • positive regulation of actin filament polymerization; • Fc-gamma receptor signaling pathway involved in phagocytosis; • فسفرگیری; • transmembrane receptor protein tyrosine kinase signaling pathway; • cytokine-mediated signaling pathway; • interferon-gamma-mediated signaling pathway; • immune system process; • leukocyte degranulation; • negative regulation of apoptotic process; • GO:0019049، GO:0030683 mitigation of host defenses by virus; • protein phosphorylation; • چسبندگی سلولی; • respiratory burst after phagocytosis; • regulation of DNA-binding transcription factor activity; • positive regulation of cell population proliferation; • regulation of inflammatory response; • regulation of cell shape; • regulation of podosome assembly; • peptidyl-tyrosine autophosphorylation; • بیگانه‌خواری; • integrin-mediated signaling pathway; • protein autophosphorylation; • peptidyl-tyrosine phosphorylation; • regulation of phagocytosis; • mesoderm development; • inflammatory response; • innate immune response-activating signal transduction; • positive regulation of actin cytoskeleton reorganization; • lipopolysaccharide-mediated signaling pathway; • اگزوسیتوز; • GO:0022415 viral process; • دستگاه ایمنی ذاتی;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3055
	15162
	ENSG00000101336
	ENSMUSG00000003283
	P08631
	P08103
	NM_001172129، NM_001172130، NM_001172131، NM_001172132، NM_001172133 NM_002110، NM_001172129، NM_001172130، NM_001172131، NM_001172132، NM_001172133
	NM_010407 NM_001172117، NM_010407
	NP_001165601، NP_001165602، NP_001165603، NP_001165604، NP_002101 NP_001165600، NP_001165601، NP_001165602، NP_001165603، NP_001165604، NP_002101
	NP_034537 NP_001165588، NP_034537
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

تیروزین-پروتئین کیناز HCK (انگلیسی: Tyrosine-protein kinase HCK) یک آنزیم است که در انسان توسط ژن «HCK» کُدگذاری می‌شود.^[۴]

این پروتئین با گیرنده فاکتور محرک کلونی گرانولوسیت^[۵] و RASA1^[۶] تعامل پروتئین-پروتئین دارد.

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003283 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD (August 1987). "Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells". Mol Cell Biol. 7 (6): 2267–75. PMC 365351. PMID 3496523.
↑ Ward AC, Monkhouse JL, Csar XF, Touw IP, Bello PA (Oct 1998). "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". Biochemical and Biophysical Research Communications. 251 (1): 117–23. doi:10.1006/bbrc.1998.9441. PMID 9790917.
↑ Briggs SD, Bryant SS, Jove R, Sanderson SD, Smithgall TE (Jun 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". The Journal of Biological Chemistry. 270 (24): 14718–24. doi:10.1074/jbc.270.24.14718. PMID 7782336.

مشارکت‌کنندگان ویکی‌پدیا. «HCK». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

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Lock P, Ralph S, Stanley E, Boulet I, Ramsay R, Dunn AR (1991). "Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization". Mol. Cell. Biol. 11 (9): 4363–70. PMC 361298. PMID 1875927.
Ziegler SF, Marth JD, Lewis DB, Perlmutter RM (1987). "Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin". Mol. Cell. Biol. 7 (6): 2276–85. PMC 365352. PMID 3453117.
Lee CH, Leung B, Lemmon MA, Zheng J, Cowburn D, Kuriyan J, Saksela K (1995). "A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein". EMBO J. 14 (20): 5006–15. PMC 394604. PMID 7588629.
Liao F, Shin HS, Rhee SG (1993). "In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases". Biochem. Biophys. Res. Commun. (Submitted manuscript). 191 (3): 1028–33. doi:10.1006/bbrc.1993.1320. PMID 7682059.
Briggs SD, Bryant SS, Jove R, Sanderson SD, Smithgall TE (1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". J. Biol. Chem. 270 (24): 14718–24. doi:10.1074/jbc.270.24.14718. PMID 7782336.
Robbins SM, Quintrell NA, Bishop JM (1995). "Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae". Mol. Cell. Biol. 15 (7): 3507–15. PMC 230587. PMID 7791757.
Saksela K, Cheng G, Baltimore D (1995). "Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4". EMBO J. 14 (3): 484–91. PMC 398106. PMID 7859737.
Cheng G, Ye ZS, Baltimore D (1994). "Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction". Proc. Natl. Acad. Sci. U.S.A. 91 (17): 8152–5. doi:10.1073/pnas.91.17.8152. PMC 44563. PMID 8058772.
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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003283 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3496523-4] Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD (August 1987). "Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells". Mol Cell Biol. 7 (6): 2267–75. PMC 365351. PMID 3496523.

[pmid9790917-5] Ward AC, Monkhouse JL, Csar XF, Touw IP, Bello PA (Oct 1998). "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". Biochemical and Biophysical Research Communications. 251 (1): 117–23. doi:10.1006/bbrc.1998.9441. PMID 9790917.

[pmid7782336-6] Briggs SD, Bryant SS, Jove R, Sanderson SD, Smithgall TE (Jun 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". The Journal of Biological Chemistry. 270 (24): 14718–24. doi:10.1074/jbc.270.24.14718. PMID 7782336.

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آنزیم‌ها
فعالیت	جایگاه فعال جایگاه اتصال سه‌گانه کاتالیزگر Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme کوآنزیم کوفاکتور کاتالیز آنزیم
قواعد	دگرریختاری Cooperativity بازدارنده آنزیم فعال‌کننده آنزیم
دسته‌بندی	عدد گروه آنزیم ابرخانواده آنزیم خانواده آنزیم فهرست آنزیم‌ها
سینتیک	سینتیک میکائلیس–منتن طرح ادی هوفستی طرح لاینویور برک طرح هانس وولف
انواع	ای‌سی۱ اکسیدوردوکتازها (فهرست) ای‌سی۲ ترانسفرازها (فهرست) ای‌سی۳ هیدرولازها (فهرست) ای‌سی۴ لیازها (فهرست) ای‌سی۵ ایزومرازها (فهرست) ای‌سی۶ لیگازها (فهرست) ای‌سی۷ ترنسلوکازها (فهرست)