MMP10
استروملیسین ۲ (انگلیسی: Stromelysin-2) که با نام «متالوپروتئیناز ۱۰ ماتریکس» (MMP-10) و «ترانسین ۲» هم شناخته میشود، یک پروتئین است که در انسان توسط ژن «MMP10» کُدگذاری میشود.[۴][۵]
عملکرد
این آنزیم در تجزیهٔ ماتریکس برونیاختهای طی فرایندهای طبیعی فیزیولوژیک همچون رشد رویان، تولیدمثل و بازآرایی بافتی و همچنین فرایندهای برخی بیماریها نظیر آرتریتها و متاستازهای سرطانی[۶] نقش دارد.
منابع
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047562 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R (July 1988). "The collagenase gene family in humans consists of at least four members". The Biochemical Journal. 253 (1): 187–92. doi:10.1042/bj2530187. PMC 1149273. PMID 2844164.
- ↑ Jung JY, Warter S, Rumpler Y (1990). "Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization". Annales de Génétique. 33 (1): 21–3. PMID 2369069.
- ↑ Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP (2012). "Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential". PLOS ONE. 7 (4): e35040. doi:10.1371/journal.pone.0035040. PMC 3335833. PMID 22545096.
- مشارکتکنندگان ویکیپدیا. «MMP10». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۱۲ مارس ۲۰۲۰.
برای مطالعهٔ بیشتر
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پیوند به بیرون
- خلاصهای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونیپروت: P09238 (Stromelysin-2) در PDBe-KB.
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