MYB

MYB
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1GUU, 1GV2, 1GV5, 1GVD, 1H88, 1H89, 1IDY, 1IDZ, 1MBE, 1MBF, 1MBG, 1MBH, 1MBJ, 1MBK, 1MSE, 1MSF, 1SB0, 2AGH
معین‌کننده‌ها
نام‌های دیگر	MYB, Cmyb, c-myb, c-myb_CDS, efg, MYB proto-oncogene, transcription factor
شناسه‌های بیرونی	OMIM: 189990 MGI: 97249 HomoloGene: 31311 GeneCards: MYB
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۰ (موش)
پایان	21,036,883 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
ترکیبات سلولی	• ماتریکس هسته ای; • هسته یاخته; • نوکلئوپلاسم;
فرایند زیستی	• GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • chromatin remodeling; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of histone H3-K4 methylation; • transcription, DNA-templated; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of histone H3-K9 methylation; • positive regulation of T-helper cell differentiation; • transcription by RNA polymerase II; • GO:0007067 رشتمان; • response to hypoxia; • positive regulation of collagen biosynthetic process; • positive regulation of neuron apoptotic process; • positive regulation of smooth muscle cell proliferation; • positive regulation of glial cell proliferation; • cellular response to hydrogen peroxide; • cellular response to retinoic acid; • positive regulation of transforming growth factor beta production; • positive regulation of neuron death; • positive regulation of hepatic stellate cell proliferation; • positive regulation of hepatic stellate cell activation; • positive regulation of testosterone secretion; • regulation of hematopoietic stem cell differentiation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4602
	17863
	ENSG00000118513
	ENSMUSG00000019982
	P10242; Q708E1
	P06876
	NM_001130173، NM_001161656، NM_001161657، NM_001161658، NM_001161659، NM_001161660، NM_005375، XR_942444، NR_134958، NR_134959، NR_134960، NR_134961، NR_134962، NR_134963، NR_134964، NR_134965، XM_047418834 NM_001130172، NM_001130173، NM_001161656، NM_001161657، NM_001161658، NM_001161659، NM_001161660، NM_005375، XR_942444، NR_134958، NR_134959، NR_134960، NR_134961، NR_134962، NR_134963، NR_134964، NR_134965، XM_047418834
	NM_010848، NM_033597 NM_001198914، NM_010848، NM_033597
	NP_001123645، NP_001155128، NP_001155129، NP_001155130، NP_001155131، NP_001155132، NP_005366 NP_001123644، NP_001123645، NP_001155128، NP_001155129، NP_001155130، NP_001155131، NP_001155132، NP_005366
	NP_034978 NP_001185843، NP_034978
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

ساختارهای پروتئینی در دسترس:
پی‌فم	structures / ECOD
پی‌دی‌بی	RCSB PDB; PDBe; PDBj
پی‌دی‌بی‌سام	structure summary

دومین شبه MYB متصل‌شونده به دی‌ان‌ای
دومین شبه MYB متصل‌شونده به دی‌ان‌ای
شناسه‌ها
نماد	Myb_DNA-binding
پی‌فم	PF00249
اینترپرو	IPR001005
PROSITE	PDOC00037
CATH	1irz
SCOPe	1irz / SUPFAM
سی‌دی‌دی	cd00167
پی‌فم
ساختارهای پروتئینی در دسترس:
پی‌فم	structures / ECOD
پی‌دی‌بی	RCSB PDB; PDBe; PDBj
پی‌دی‌بی‌سام	structure summary

ژن‌های MYB عضوی از خانوادهٔ ژن‌های فاکتور رونویسی است که در حیوانات و گیاهان یافت می‌شود. در انسان، این ژن‌ها علاوه بر «MYB خالص»، شامل MYBL1 و MYBL2 هم هست.^[۴]^[۵]

نوعی از این ژن در آلفا-رتروویروس‌ها دیده می‌شوند که در پرندگان و به‌ویژه مرغ‌ها سرطان خون ایجاد می‌کند.^[۶]^[۷]

در حیوانات نیز همچون ویروس، پروتئین حاصل از این ژن یک آنکوژن (پروتئین سرطان‌زا) است.^[۷]

در گیاهان این ژن در فرایند ساخت برخی مواد شیمیایی دخیل است؛ مثلاً در ذرت خوشه‌ای دورنگ وجودِ این ژن و پروتئین حاصل از آن برای ساخت فلاوان-۴-ال ضروری است.^[۸]^[۹] در مُرَکَّبات حضور این ژن در ساخت آنتوسیانین نقش دارد؛ مثلاً علت قرمز بودن پرتقال‌های توسُرخ، همین مادهٔ آنتوسیانین است که میزان تولیدش به سبب بیش‌فعالی این ژن افزایش یافته است.^[۱۰]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019982 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X (Jul 2007). "The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells". Biochem Biophys Res Commun. 360 (2): 433–6. doi:10.1016/j.bbrc.2007.06.078. PMID 17599807.
↑ "Entrez Gene: v-myb myeloblastosis viral oncogene homolog (avian)".
↑ Klempnauer KH, Symonds G, Evan GI, Bishop JM (June 1984). "Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by chicken c-myb gene". Cell. 37 (2): 537–47. doi:10.1016/0092-8674(84)90384-2. PMID 6327074. S2CID 46196167.
1 2 George OL, Ness SA (October 2014). "Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis". Cancers. 6 (4): 2049–71. doi:10.3390/cancers6042049. PMC 4276956. PMID 25279451.
↑ Boddu J, Svabek C, Ibraheem F, Jones AD, Chopra S (2005). "Characterization of a deletion allele of a sorghum Myb gene yellow seedl showing loss of 3-deoxyflavonoids". Plant Science. 169 (3): 542–552. doi:10.1016/j.plantsci.2005.05.007. INIST:16983977
↑ Boddu J, Jiang C, Sangar V, Olson T, Peterson T, Chopra S (January 2006). "Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis". Plant Mol. Biol. 60 (2): 185–99. doi:10.1007/s11103-005-3568-1. PMID 16429259. S2CID 23841582.
↑ Butelli E, Licciardello C, Zhang Y, Liu J, Mackay S, Bailey P, Reforgiato-Recupero G, Martin C (2012). "Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges". Plant Cell. 24 (3): 1242–55. doi:10.1105/tpc.111.095232. PMC 3336134. PMID 22427337.

برای مطالعهٔ بیشتر

Oh IH, Reddy EP (1999). "The myb gene family in cell growth, differentiation and apoptosis". Oncogene. 18 (19): 3017–33. doi:10.1038/sj.onc.1202839. PMID 10378697.
Nicolaides NC, Gualdi R, Casadevall C, Manzella L, Calabretta B (1991). "Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene". Mol. Cell. Biol. 11 (12): 6166–76. doi:10.1128/mcb.11.12.6166-6176.1991. PMC 361795. PMID 1944282.
Kalkbrenner F, Guehmann S, Moelling K (1990). "Transcriptional activation by human c-myb and v-myb genes". Oncogene. 5 (5): 657–61. PMID 2189102.
Westin EH, Gorse KM, Clarke MF (1990). "Alternative splicing of the human c-myb gene". Oncogene. 5 (8): 1117–24. PMID 2202948.
Dasgupta P, Reddy EP (1990). "Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences". Oncogene. 4 (12): 1419–23. PMID 2687764.
Janssen JW, Vernole P, de Boer PA, Oosterhuis JW, Collard JG (1986). "Sublocalization of c-myb to 6q21----q23 by in situ hybridization and c-myb expression in a human teratocarcinoma with 6q rearrangements". Cytogenet. Cell Genet. 41 (3): 129–35. doi:10.1159/000132217. PMID 3007038.
Slamon DJ, Boone TC, Murdock DC, Keith DE, Press MF, Larson RA, Souza LM (1986). "Studies of the human c-myb gene and its product in human acute leukemias". Science. 233 (4761): 347–51. Bibcode:1986Sci...233..347S. doi:10.1126/science.3014652. PMID 3014652.
Majello B, Kenyon LC, Dalla-Favera R (1987). "Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus". Proc. Natl. Acad. Sci. U.S.A. 83 (24): 9636–40. doi:10.1073/pnas.83.24.9636. PMC 387195. PMID 3540945.
Szczylik C, Skorski T, Ku DH, Nicolaides NC, Wen SC, Rudnicka L, Bonati A, Malaguarnera L, Calabretta B (1993). "Regulation of proliferation and cytokine expression of bone marrow fibroblasts: role of c-myb". J. Exp. Med. 178 (3): 997–1005. doi:10.1084/jem.178.3.997. PMC 2191153. PMID 7688794.
Krieg J, Oelgeschläger M, Janknecht R, Lüscher B (1995). "High affinity DNA binding of native full length c-Myb and differential proteolytic sensitivity of its N- and C-terminal domains". Oncogene. 10 (11): 2221–8. PMID 7784067.
Jacobs SM, Gorse KM, Westin EH (1994). "Identification of a second promoter in the human c-myb proto-oncogene". Oncogene. 9 (1): 227–35. PMID 8302584.
Favier D, Gonda TJ (1994). "Detection of proteins that bind to the leucine zipper motif of c-Myb". Oncogene. 9 (1): 305–11. PMID 8302594.
Glaser R, Lafuse WP, Bonneau RH, Atkinson C, Kiecolt-Glaser JK (1993). "Stress-associated modulation of proto-oncogene expression in human peripheral blood leukocytes". Behav. Neurosci. 107 (3): 525–9. doi:10.1037/0735-7044.107.3.525. PMID 8329139.
Dash AB, Orrico FC, Ness SA (1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb". Genes Dev. 10 (15): 1858–69. doi:10.1101/gad.10.15.1858. PMID 8756344.
Vorbrueggen G, Lovrić J, Moelling K (1997). "Functional analysis of phosphorylation at serine 532 of human c-Myb by MAP kinase". Biol. Chem. 377 (11): 721–30. doi:10.1515/bchm3.1996.377.11.721. PMID 8960373.
Tavner FJ, Simpson R, Tashiro S, Favier D, Jenkins NA, Gilbert DJ, Copeland NG, Macmillan EM, Lutwyche J, Keough RA, Ishii S, Gonda TJ (1998). "Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb". Mol. Cell. Biol. 18 (2): 989–1002. doi:10.1128/MCB.18.2.989. PMC 108811. PMID 9447996.
Hedge SP, Kumar A, Kurschner C, Shapiro LH (1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Mol. Cell. Biol. 18 (5): 2729–37. doi:10.1128/mcb.18.5.2729. PMC 110652. PMID 9566892.
Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA (1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity". Mol. Cell. 2 (4): 417–25. doi:10.1016/S1097-2765(00)80141-0. PMID 9809063.
Thompson MA, Rosenthal MA, Ellis SL, Friend AJ, Zorbas MI, Whitehead RH, Ramsay RG (1998). "c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression". Cancer Res. 58 (22): 5168–75. PMID 9823328.
Verbeek W, Gombart AF, Chumakov AM, Müller C, Friedman AD, Koeffler HP (1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters". Blood. 93 (10): 3327–37. doi:10.1182/blood.V93.10.3327. PMID 10233885.

پیوند به بیرون

MYB protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019982 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17599807-4] Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X (Jul 2007). "The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells". Biochem Biophys Res Commun. 360 (2): 433–6. doi:10.1016/j.bbrc.2007.06.078. PMID 17599807.

[entrez-5] "Entrez Gene: v-myb myeloblastosis viral oncogene homolog (avian)".

[6] Klempnauer KH, Symonds G, Evan GI, Bishop JM (June 1984). "Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by chicken c-myb gene". Cell. 37 (2): 537–47. doi:10.1016/0092-8674(84)90384-2. PMID 6327074. S2CID 46196167.

[pmid25279451-7] 1 2 George OL, Ness SA (October 2014). "Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis". Cancers. 6 (4): 2049–71. doi:10.3390/cancers6042049. PMC 4276956. PMID 25279451.

[8] Boddu J, Svabek C, Ibraheem F, Jones AD, Chopra S (2005). "Characterization of a deletion allele of a sorghum Myb gene yellow seedl showing loss of 3-deoxyflavonoids". Plant Science. 169 (3): 542–552. doi:10.1016/j.plantsci.2005.05.007. INIST:16983977

[pmid16429259-9] Boddu J, Jiang C, Sangar V, Olson T, Peterson T, Chopra S (January 2006). "Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis". Plant Mol. Biol. 60 (2): 185–99. doi:10.1007/s11103-005-3568-1. PMID 16429259. S2CID 23841582.

[pmid22427337-10] Butelli E, Licciardello C, Zhang Y, Liu J, Mackay S, Bailey P, Reforgiato-Recupero G, Martin C (2012). "Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges". Plant Cell. 24 (3): 1242–55. doi:10.1105/tpc.111.095232. PMC 3336134. PMID 22427337.

[۱]

[۲]

[۳]

[۴]

[۵]

[۶]

[۷]

[۸]

[۹]

[۱۰]