PRKAA1

PRKAA1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4RED, 4RER, 4REW, 5EZV
معین‌کننده‌ها
نام‌های دیگر	PRKAA1, AMPK, AMPKa1, Protein kinase, AMP-activated, alpha 1, protein kinase AMP-activated catalytic subunit alpha 1
شناسه‌های بیرونی	OMIM: 602739 MGI: 2145955 HomoloGene: 49590 GeneCards: PRKAA1
عدد EC	2.7.11.26
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۵ (موش)
پایان	5,211,380 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • cAMP-dependent protein kinase activity; • [acetyl-CoA carboxylase kinase activity]; • AMP-activated protein kinase activity; • histone serine kinase activity; • chromatin binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • tau-protein kinase activity; • protein C-terminus binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity]; • ATP binding; • tau protein binding;
ترکیبات سلولی	• nucleotide-activated protein kinase complex; • apical plasma membrane; • نوکلئوپلاسم; • هسته یاخته; • سیتوپلاسم; • سیتوزول; • nuclear speck; • intracellular anatomical structure; • آسه; • دندریت; • GO:0009327 protein-containing complex; • soma;
فرایند زیستی	• cellular response to organonitrogen compound; • steroid metabolic process; • cellular response to glucose starvation; • sterol biosynthetic process; • lipid biosynthetic process; • GO:0009373 regulation of transcription, DNA-templated; • response to hypoxia; • cellular response to ethanol; • glucose homeostasis; • positive regulation of skeletal muscle tissue development; • protein heterooligomerization; • rhythmic process; • فسفرگیری; • سوخت‌وساز لیپید; • regulation of vesicle-mediated transport; • negative regulation of apoptotic process; • cholesterol metabolic process; • مسیر پیام‌رسانی وینت; • response to activity; • Synthesis saturated fatty acids by metabolites; • transcription, DNA-templated; • cellular response to prostaglandin E stimulus; • خودخواری; • protein phosphorylation; • negative regulation of TOR signaling; • cold acclimation; • GO:1901313 positive regulation of gene expression; • response to camptothecin; • fatty acid biosynthetic process; • fatty acid homeostasis; • regulation of circadian rhythm; • fatty acid oxidation; • regulation of peptidyl-serine phosphorylation; • cellular response to nutrient levels; • positive regulation of cell population proliferation; • negative regulation of glucosylceramide biosynthetic process; • glucose metabolic process; • positive regulation of cholesterol biosynthetic process; • response to caffeine; • cholesterol biosynthetic process; • negative regulation of lipid catabolic process; • واکنش به پرتو گاما; • macroautophagy; • واکنش به فرابنفش; • positive regulation of glycolytic process; • response to hydrogen peroxide; • cellular response to hypoxia; • GO:0072468 ورارسانی پیام; • cellular response to hydrogen peroxide; • steroid biosynthetic process; • regulation of signal transduction by p53 class mediator; • positive regulation of autophagy; • CAMKK-AMPK signaling cascade; • regulation of macroautophagy; • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization; • positive regulation of mitochondrial transcription; • positive regulation of protein targeting to mitochondrion; • negative regulation of gene expression; • cellular response to oxidative stress; • GO:0007243 intracellular signal transduction; • GO:1903105 negative regulation of insulin receptor signaling pathway; • motor behavior; • regulation of stress granule assembly; • neuron cellular homeostasis; • regulation of microtubule cytoskeleton organization; • cellular response to calcium ion; • cellular response to glucose stimulus; • energy homeostasis; • positive regulation of protein localization; • negative regulation of tubulin deacetylation; • positive regulation of peptidyl-lysine acetylation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5562
	105787
	ENSG00000132356
	ENSMUSG00000050697
	Q13131
	Q5EG47
	NM_006251، NM_206907، XM_017009624، XM_017009625 XM_006714482، NM_006251، NM_206907، XM_017009624، XM_017009625
	NM_001355640، XM_036159053 NM_001013367، NM_001355640، XM_036159053
	NP_996790، XP_016865113، XP_016865114، NP_001341957، NP_001341958، NP_001341963، NP_001341964، NP_001341965، NP_001341966 NP_006242، NP_996790، XP_016865113، XP_016865114، NP_001341957، NP_001341958، NP_001341963، NP_001341964، NP_001341965، NP_001341966
	NP_001342569، XP_036014946 NP_001013385، NP_001342569، XP_036014946
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

زیرواحد آلفا-۱ کاتالیتیک پروتئین کیناز فعال‌شده با ۵'-آدنوزین مونوفسفات (انگلیسی: 5'-AMP-activated protein kinase catalytic subunit alpha-1) که با نام «AMPKa1» هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «PRKAA1» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین متعلق به خانوادهٔ پروتئین کینازهای اختصاصی سرین/ترئونین است. ثابت شده که طی پیرایش دگرسان، نسخهٔ‌های رونویسی مختلفی از این ژن که ایزوفرم‌های گوناگونی را پدیدمی‌آوردند، به وجود می‌آید.^[۵]

این پروتئین با مولکول TSC2^[۶]^[۷] تعامل پروتئین-پروتئین دارد.

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050697 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem. 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660.
1 2 "Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit".
↑ Inoki, Ken; Zhu Tianqing; Guan Kun-Liang (Nov 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell. United States. 115 (5): 577–90. doi:10.1016/S0092-8674(03)00929-2. ISSN 0092-8674. PMID 14651849. S2CID 18173817.
↑ Shaw, Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell. United States. 6 (1): 91–9. doi:10.1016/j.ccr.2004.06.007. ISSN 1535-6108. PMID 15261145.

مشارکت‌کنندگان ویکی‌پدیا. «Protein kinase, AMP-activated, alpha 1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۶ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر

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Woods A, Cheung PC, Smith FC, et al. (1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro". J. Biol. Chem. 271 (17): 10282–90. doi:10.1074/jbc.271.48.30517. PMID 8626596.
Hawley SA, Davison M, Woods A, et al. (1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase". J. Biol. Chem. 271 (44): 27879–87. doi:10.1074/jbc.271.44.27879. PMID 8910387.
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Crute BE, Seefeld K, Gamble J, et al. (1999). "Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase". J. Biol. Chem. 273 (52): 35347–54. doi:10.1074/jbc.273.52.35347. PMID 9857077.
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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050697 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8557660-4] Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem. 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660.

[entrez-5] 1 2 "Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit".

[pmid14651849-6] Inoki, Ken; Zhu Tianqing; Guan Kun-Liang (Nov 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell. United States. 115 (5): 577–90. doi:10.1016/S0092-8674(03)00929-2. ISSN 0092-8674. PMID 14651849. S2CID 18173817.

[pmid15261145-7] Shaw, Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell. United States. 6 (1): 91–9. doi:10.1016/j.ccr.2004.06.007. ISSN 1535-6108. PMID 15261145.

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