RB1CC1

RB1CC1
معین‌کننده‌ها
نام‌های دیگر	RB1CC1, ATG17, CC1, FIP200, PPP1R131, RB1 inducible coiled-coil 1
شناسه‌های بیرونی	OMIM: 606837 MGI: 1341850 HomoloGene: 7659 GeneCards: RB1CC1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	6,276,648 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • protein kinase binding; • GO:0032947 molecular adaptor activity;
ترکیبات سلولی	• phagophore assembly site membrane; • پوشش هسته‌ای; • Atg1/ULK1 kinase complex; • phagophore assembly site; • هسته یاخته; • سیتوپلاسم; • endoplasmic reticulum membrane; • سیتوزول; • extrinsic component of membrane; • کافنده‌تن;
فرایند زیستی	• positive regulation of protein phosphorylation; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of extrinsic apoptotic signaling pathway; • negative regulation of apoptotic process; • autophagosome assembly; • transcription, DNA-templated; • development of the heart; • positive regulation of cell size; • چرخه یاخته‌ای; • liver development; • macroautophagy; • خودخواری; • positive regulation of JNK cascade; • میتوفاژی; • autophagy of peroxisome; • reticulophagy; • glycophagy; • regulation of macroautophagy; • piecemeal microautophagy of the nucleus;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	9821
	12421
	ENSG00000023287
	ENSMUSG00000025907
	Q8TDY2
	Q9ESK9
	NM_001083617، NM_014781، XM_011517643، XM_011517644، XM_011517645، XM_011517647، XM_011517649، XM_017014103، XM_017014104، XM_017014105، XM_017014106، XM_017014107، XM_017014108، XM_017014109، XM_047422494، XM_047422495، XM_047422496، XM_047422497 XR_928826، NM_001083617، NM_014781، XM_011517643، XM_011517644، XM_011517645، XM_011517647، XM_011517649، XM_017014103، XM_017014104، XM_017014105، XM_017014106، XM_017014107، XM_017014108، XM_017014109، XM_047422494، XM_047422495، XM_047422496، XM_047422497
	XM_006495443، XM_011238338، XM_011238339، XM_011238340، XM_011238341 NM_009826، XM_006495443، XM_011238338، XM_011238339، XM_011238340، XM_011238341
	NP_055596، XP_011515945، XP_011515946، XP_011515947، XP_011515948، XP_011515949، XP_011515951، XP_016869592، XP_016869593، XP_016869594، XP_016869595، XP_016869596، XP_016869597، XP_016869598، XP_016869599، XP_016869600، XP_016869601 NP_001077086، NP_055596، XP_011515945، XP_011515946، XP_011515947، XP_011515948، XP_011515949، XP_011515951، XP_016869592، XP_016869593، XP_016869594، XP_016869595، XP_016869596، XP_016869597، XP_016869598، XP_016869599، XP_016869600، XP_016869601
	XP_006495506، XP_011236640، XP_011236641، XP_011236642، XP_011236643، XP_036012136، XP_036012140، XP_036012163، XP_036012191، XP_036012219، XP_036012227 NP_033956، XP_006495506، XP_011236640، XP_011236641، XP_011236642، XP_011236643، XP_036012136، XP_036012140، XP_036012163، XP_036012191، XP_036012219، XP_036012227
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین ۱ خم‌شدۀ خمیدۀ القاشونده توسط آربی۱ (انگلیسی: RB1-inducible coiled-coil protein 1) یک پروتئین است که در انسان توسط ژن «RB1CC1» کُدگذاری می‌شود.^[۴]^[۵]^[۶]^[۷]

این پروتئین با مولکول های PTK2B،^[۸] ASK1^[۹] و PTK2 تعامل پروتئین-پروتئین دارد.^[۸]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025907 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chano T, Ikegawa S, Kontani K, Okabe H, Baldini N, Saeki Y (Feb 2002). "Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells". Oncogene. 21 (8): 1295–8. doi:10.1038/sj.onc.1205171. PMID 11850849. S2CID 1446211.
↑ Maucuer A, Camonis JH, Sobel A (Apr 1995). "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains". Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3100–4. doi:10.1073/pnas.92.8.3100. PMC 42112. PMID 7724523.
↑ Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N (May 2008). "FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells". The Journal of Cell Biology. 181 (3): 497–510. doi:10.1083/jcb.200712064. PMC 2364687. PMID 18443221.
↑ "Entrez Gene: RB1CC1 RB1-inducible coiled-coil 1".
1 2 Ueda H, Abbi S, Zheng C, Guan JL (Apr 2000). "Suppression of Pyk2 kinase and cellular activities by FIP200". The Journal of Cell Biology. 149 (2): 423–30. doi:10.1083/jcb.149.2.423. PMC 2175150. PMID 10769033.
↑ Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL (Oct 2006). "Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways". The Journal of Cell Biology. 175 (1): 121–33. doi:10.1083/jcb.200604129. PMC 2064504. PMID 17015619.

مشارکت‌کنندگان ویکی‌پدیا. «RB1CC1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر

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Ueda H, Abbi S, Zheng C, Guan JL (Apr 2000). "Suppression of Pyk2 kinase and cellular activities by FIP200". The Journal of Cell Biology. 149 (2): 423–30. doi:10.1083/jcb.149.2.423. PMC 2175150. PMID 10769033.
Chano T, Kontani K, Teramoto K, Okabe H, Ikegawa S (Jul 2002). "Truncating mutations of RB1CC1 in human breast cancer". Nature Genetics. 31 (3): 285–8. doi:10.1038/ng911. PMID 12068296. S2CID 23884140.
Chano T, Ikegawa S, Saito-Ohara F, Inazawa J, Mabuchi A, Saeki Y, Okabe H (May 2002). "Isolation, characterization and mapping of the mouse and human RB1CC1 genes". Gene. 291 (1–2): 29–34. doi:10.1016/S0378-1119(02)00585-1. PMID 12095676.
Chano T, Saeki Y, Serra M, Matsumoto K, Okabe H (Aug 2002). "Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells". The American Journal of Pathology. 161 (2): 359–64. doi:10.1016/S0002-9440(10)64190-9. PMC 1850752. PMID 12163359.
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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025907 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11850849-4] Chano T, Ikegawa S, Kontani K, Okabe H, Baldini N, Saeki Y (Feb 2002). "Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells". Oncogene. 21 (8): 1295–8. doi:10.1038/sj.onc.1205171. PMID 11850849. S2CID 1446211.

[pmid7724523-5] Maucuer A, Camonis JH, Sobel A (Apr 1995). "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains". Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3100–4. doi:10.1073/pnas.92.8.3100. PMC 42112. PMID 7724523.

[pmid18443221-6] Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N (May 2008). "FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells". The Journal of Cell Biology. 181 (3): 497–510. doi:10.1083/jcb.200712064. PMC 2364687. PMID 18443221.

[entrez-7] "Entrez Gene: RB1CC1 RB1-inducible coiled-coil 1".

[pmid10769033-8] 1 2 Ueda H, Abbi S, Zheng C, Guan JL (Apr 2000). "Suppression of Pyk2 kinase and cellular activities by FIP200". The Journal of Cell Biology. 149 (2): 423–30. doi:10.1083/jcb.149.2.423. PMC 2175150. PMID 10769033.

[pmid17015619-9] Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL (Oct 2006). "Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways". The Journal of Cell Biology. 175 (1): 121–33. doi:10.1083/jcb.200604129. PMC 2064504. PMID 17015619.

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