SIX5

SIX5
معین‌کننده‌ها
نام‌های دیگر	SIX5, BOR2, DMAHP, SIX homeobox 5
شناسه‌های بیرونی	OMIM: 600963 MGI: 106220 HomoloGene: 72248 GeneCards: SIX5
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	18,832,474 bp
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • sequence-specific DNA binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000975 transcription cis-regulatory region binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific;
ترکیبات سلولی	• هسته یاخته; • سیتوپلاسم; • transcription regulator complex;
فرایند زیستی	• multicellular organism development; • negative regulation of cell population proliferation; • lens development in camera-type eye; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • spermatid development; • negative regulation of skeletal muscle satellite cell proliferation; • GO:1903374 anatomical structure development;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	147912
	20475
	ENSG00000177045
	ENSMUSG00000040841
	Q8N196
	P70178
	NM_175875
	XM_006539694 NM_011383، XM_006539694
	NP_787071
	XP_006539757 NP_035513، XP_006539757
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین هومئوباکس SIX5 پروتئینی است که در انسان توسط ژن SIX5 کدگذاری می شود.^[۴]^[۵]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040841 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL (Apr 1996). "A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat". Hum Mol Genet. 4 (10): 1919–25. doi:10.1093/hmg/4.10.1919. PMID 8595416.
↑ "Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)".

جهت مطالعه

Murakami Y, Ohto H, Ikeda U, Shimada K, Momoi T, Kawakami K (1999). "Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements". Hum. Mol. Genet. 7 (13): 2103–12. doi:10.1093/hmg/7.13.2103. PMID 9817928.
Winchester CL, Ferrier RK, Sermoni A, Clark BJ, Johnson KJ (1999). "Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy". Hum. Mol. Genet. 8 (3): 481–92. doi:10.1093/hmg/8.3.481. PMID 9949207.
Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K (2000). "Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya". Mol. Cell. Biol. 19 (10): 6815–24. doi:10.1128/mcb.19.10.6815. PMC 84678. PMID 10490620.
Harris SE, Winchester CL, Johnson KJ (2000). "Functional analysis of the homeodomain protein SIX5". Nucleic Acids Res. 28 (9): 1871–8. doi:10.1093/nar/28.9.1871. PMC 103302. PMID 10756185.
Winchester C, Robertson S, MacLeod T, Johnson K, Thomas M (2000). "Expression of a homeobox gene (SIX5) in borderline ovarian tumours". J. Clin. Pathol. 53 (3): 212–7. doi:10.1136/jcp.53.3.212. PMC 1731149. PMID 10823141.
Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
Sato S, Nakamura M, Cho DH, Tapscott SJ, Ozaki H, Kawakami K (2002). "Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1". Hum. Mol. Genet. 11 (9): 1045–58. doi:10.1093/hmg/11.9.1045. PMID 11978764.
Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P (2003). "Six and Eya expression during human somitogenesis and MyoD gene family activation". J. Muscle Res. Cell. Motil. 23 (3): 255–64. doi:10.1023/A:1020990825644. PMID 12500905. S2CID 42497614.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Hoskins BE, Cramer CH, Silvius D, Zou D, Raymond RM, Orten DJ, Kimberling WJ, Smith RJ, Weil D, Petit C, Otto EA, Xu PX, Hildebrandt F (2007). "Transcription Factor SIX5 Is Mutated in Patients with Branchio-Oto-Renal Syndrome". Am. J. Hum. Genet. 80 (4): 800–4. doi:10.1086/513322. PMC 1852719. PMID 17357085.

پیوند به بیرون

SIX5 در دانشنامهٔ اجزای دی‌ان‌ای

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040841 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8595416-4] Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL (Apr 1996). "A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat". Hum Mol Genet. 4 (10): 1919–25. doi:10.1093/hmg/4.10.1919. PMID 8595416.

[entrez-5] "Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)".

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