لسیتین-کلسترول اسیل‌ترانسفراز
لسیتین-کلسترول اسیل‌ترانسفراز (انگلیسی: Lecithin–cholesterol acyltransferase) که با نام اختصاری LCAT هم شناخته می‌شود، یک آنزیم است که کلسترول را به کلستریل استر (یک نوع کلسترول آب‌گریز) مبدل می‌کند که در هستهٔ یک ذرهٔ لیپوپروتئینی گرد هم آمده و در نهایت یک کرهٔ لیپوپروتئین پرچگالی ایجاد می‌کند و واکنش شیمیایی را بالاجبار یک‌طرفه می‌کند. این آنزیم در پلاسمای خون به لیپوپروتئین پرچگالی (آلفا-ال‌سی‌ای‌تی) و لیپوپروتئین کم‌چگالی (بتا-ال‌سی‌ای‌تی) متصل است.[۴] کمبود این آنزیم به دلیل کدر کردن قرنیه توسط کلسترول سبب اختلالات بینایی گشته و همچنین کم‌خونی و آسیب به کلیه‌ها را به‌دنبال دارد.[۵]
نقشهٔ هم‌کنشی مسیرهای شیمیایی
با کلیک کردن بر روی نام ژن‌ها و پروتئین‌ها در نقشهٔ زیر، به مقالهٔ مربوط هدایت خواهید شد. Click on genes, proteins and metabolites below to link to respective articles. [§ ۱]
- ↑ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".
منابع
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035237 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Lecithin-Cholesterol Acyltransferase Deficiency: Overview, Presentation, Differential Diagnosis". 2016-08-08.
{{cite journal}}: Cite journal requires|journal=(help) - ↑ Reference, Genetics Home. "LCAT gene". Genetics Home Reference. Retrieved 2016-12-11.
- مشارکت‌کنندگان ویکی‌پدیا. «Lecithin–cholesterol acyltransferase». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۴ ژانویه ۲۰۲۱.
برای مطالعهٔ بیشتر
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