ADCYAP1R1

ADCYAP1R1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2JOD
معین‌کننده‌ها
نام‌های دیگر	ADCYAP1R1, PAC1, PAC1R, PACAPR, PACAPRI, ADCYAP receptor type I
شناسه‌های بیرونی	OMIM: 102981 MGI: 108449 HomoloGene: 870 GeneCards: ADCYAP1R1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۶ (موش)
پایان	55,478,436 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• G protein-coupled receptor activity; • adenylate cyclase binding; • neuropeptide binding; • vasoactive intestinal polypeptide receptor activity; • signal transducer activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • transmembrane signaling receptor activity; • signaling receptor activity; • G protein-coupled peptide receptor activity; • peptide hormone binding;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • اندوزوم; • rough endoplasmic reticulum; • membrane; • bicellular tight junction; • receptor complex; • پوسته یاخته; • integral component of plasma membrane; • cell surface; • حفره غشایی; • neuron projection; • intracellular membrane-bounded organelle;
فرایند زیستی	• دگرگونی یاخته‌; • multicellular organismal response to stress; • response to estradiol; • positive regulation of calcium ion transport into cytosol; • positive regulation of inositol phosphate biosynthetic process; • negative regulation of cell death; • activation of phospholipase C activity; • multicellular organism development; • cell surface receptor signaling pathway; • development of primary female sexual characteristics; • اسپرماتوژنز; • response to ethanol; • cAMP-mediated signaling; • GO:0072468 ورارسانی پیام; • positive regulation of small GTPase mediated signal transduction; • G protein-coupled receptor signaling pathway; • positive regulation of cAMP-mediated signaling;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	117
	11517
	ENSG00000078549
	ENSMUSG00000029778
	P41586
	P70205
	NM_001199635، NM_001199636، NM_001199637، XM_005249618، XM_006715645، XM_017011736، XM_017011737، XM_017011738، XM_047419879 NM_001118، NM_001199635، NM_001199636، NM_001199637، XM_005249618، XM_006715645، XM_017011736، XM_017011737، XM_017011738، XM_047419879
	NM_007407، XM_006505388، XM_011241150، XM_011241151، XM_011241152، XM_011241153، XM_030255112، XM_030255113، XM_030255114، XM_036165754، XR_004942912 NM_001025372، NM_007407، XM_006505388، XM_011241150، XM_011241151، XM_011241152، XM_011241153، XM_030255112، XM_030255113، XM_030255114، XM_036165754، XR_004942912
	NP_001186564، NP_001186565، NP_001186566، XP_005249675، XP_006715708، XP_016867225، XP_016867226، XP_016867227 NP_001109، NP_001186564، NP_001186565، NP_001186566، XP_005249675، XP_006715708، XP_016867225، XP_016867226، XP_016867227
	NP_031433، XP_006505451، XP_011239452، XP_011239453، XP_011239454، XP_011239455، XP_030110972، XP_030110973، XP_030110974، XP_036021647 NP_001020543، NP_031433، XP_006505451، XP_011239452، XP_011239453، XP_011239454، XP_011239455، XP_030110972، XP_030110973، XP_030110974، XP_036021647
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرندهٔ پُلی‌پپتید فعال‌کننده آدنیلات سیکلاز هیپوفیز نوع ۱ (انگلیسی: ADCYAP1R1) یا به‌اختصار PAC₁ یک پروتئین است که در انسان توسط ژن «ADCYAP1R1» کدگذاری می‌شود.^[۴]

این گیرنده به پپتید فعال‌کننده آدنیلات سیکلاز هیپوفیز اتصال می‌یابد^[۵]^[۶] و شباهت ساختاری فراوانی با گیرنده‌های جفت‌شونده با پروتئین جی کلاس B (خانوادهٔ گیرنده‌های سکرتین) دارد. این پروتئین در بخش قشری عدهٔ فوق‌کلیوی، لوزالمعده، رحم، شبکه میانتریک روده و مغز بیان می‌شود.^[۷]^[۸]^[۹] این گیرنده همچنین در گانگلیون‌های عصبی «سه‌قلو»، «گوشی» و «گردنی فوقانی» (پیش‌اتصالی) و همچنین شریان‌های مغزی (پس‌اتصالی) یافت می‌شود.^[۱۰]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029778 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I".
↑ Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
↑ Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (Jun 2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacological Reviews. 52 (2): 269–324. PMID 10835102. Archived from the original on 5 July 2008. Retrieved 24 December 2018.
↑ Reubi JC (2000). "In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications". Annals of the New York Academy of Sciences. 921: 1–25. doi:10.1111/j.1749-6632.2000.tb06946.x. PMID 11193811.
↑ Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (Jun 2000). "Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin". Cancer Research. 60 (11): 3105–12. PMID 10850463.
↑ Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation". The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1299–305. doi:10.1210/jc.83.4.1299. PMID 9543159.
↑ Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport. 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171.

مشارکت‌کنندگان ویکی‌پدیا. «ADCYAP1R1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۸.

بیشتر بخوانید

Stoffel M, Espinosa R, Trabb JB, Le Beau MM, Bell GI (Oct 1994). "Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7". Genomics. 23 (3): 697–9. doi:10.1006/geno.1994.1560. PMID 7851900.
Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
Ohtaki T, Masuda Y, Ishibashi Y, Kitada C, Arimura A, Fujino M (Dec 1993). "Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide". The Journal of Biological Chemistry. 268 (35): 26650–7. PMID 8253796.
Pisegna JR, Wank SA (Jul 1996). "Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C". The Journal of Biological Chemistry. 271 (29): 17267–74. doi:10.1074/jbc.271.29.17267. PMID 8663363.
Pantaloni C, Brabet P, Bilanges B, Dumuis A, Houssami S, Spengler D, Bockaert J, Journot L (Sep 1996). "Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation". The Journal of Biological Chemistry. 271 (36): 22146–51. doi:10.1074/jbc.271.36.22146. PMID 8703026.
Solano RM, Carmena MJ, Carrero I, Cavallaro S, Roman F, Hueso C, Travali S, Lopez-Fraile N, Guijarro LG, Prieto JC (Jul 1996). "Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate". Endocrinology. 137 (7): 2815–22. doi:10.1210/en.137.7.2815. PMID 8770902.
Wei Y, Mojsov S (Nov 1996). "Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology". Journal of Neuroendocrinology. 8 (11): 811–7. doi:10.1046/j.1365-2826.1996.05191.x. PMID 8933357.
Brabet P, Diriong S, Journot L, Bockaert J, Taviaux S (Nov 1996). "Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization". Genomics. 38 (1): 100–2. doi:10.1006/geno.1996.0600. PMID 8954788.
Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation". The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1299–305. doi:10.1210/jc.83.4.1299. PMID 9543159.
Steinhoff M, McGregor GP, Radleff-Schlimme A, Steinhoff A, Jarry H, Schmidt WE (Mar 1999). "Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis". Regulatory Peptides. 80 (1–2): 49–55. doi:10.1016/S0167-0115(99)00010-5. PMID 10235634.
Zeng N, Athmann C, Kang T, Lyu RM, Walsh JH, Ohning GV, Sachs G, Pisegna JR (Nov 1999). "PACAP type I receptor activation regulates ECL cells and gastric acid secretion". The Journal of Clinical Investigation. 104 (10): 1383–91. doi:10.1172/JCI7537. PMC 409843. PMID 10562300.
Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL (Dec 1999). "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". Journal of Neuroendocrinology. 11 (12): 941–9. doi:10.1046/j.1365-2826.1999.00411.x. PMID 10583729.
Scaldaferri ML, Modesti A, Palumbo C, Ulisse S, Fabbri A, Piccione E, Frajese G, Moretti C (Mar 2000). "Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta". Endocrinology. 141 (3): 1158–67. doi:10.1210/en.141.3.1158. PMID 10698193.
Busto R, Prieto JC, Bodega G, Zapatero J, Carrero I (Feb 2000). "Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung". Peptides. 21 (2): 265–9. doi:10.1016/S0196-9781(99)00202-8. PMID 10764955.
Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport. 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171.
Miampamba M, Germano PM, Arli S, Wong HH, Scott D, Taché Y, Pisegna JR (May 2002). "Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons". Regulatory Peptides. 105 (3): 145–54. doi:10.1016/S0167-0115(02)00003-4. PMID 11959368.
Le SV, Yamaguchi DJ, McArdle CA, Tachiki K, Pisegna JR, Germano P (Nov 2002). "PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells". Regulatory Peptides. 109 (1–3): 115–25. doi:10.1016/S0167-0115(02)00194-5. PMID 12409223.
Ronaldson E, Robertson DN, Johnson MS, Holland PJ, Mitchell R, Lutz EM (Nov 2002). "Specific interaction between the hop1 intracellular loop 3 domain of the human PAC(1) receptor and ARF". Regulatory Peptides. 109 (1–3): 193–8. doi:10.1016/S0167-0115(02)00204-5. PMID 12409233.
Isobe K, Tatsuno I, Yashiro T, Nanmoku T, Takekoshi K, Kawakami Y, Nakai T (Feb 2003). "Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis". Regulatory Peptides. 110 (3): 213–7. doi:10.1016/S0167-0115(02)00209-4. PMID 12573802.

پیوند به بیرون

مکان ژنوم ADCYAP1R1 انسانی و صفحهٔ جزئیات ژنی ADCYAP1R1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029778 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I".

[pmid_7902709-5] Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.

[pmid_10835102-6] Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (Jun 2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacological Reviews. 52 (2): 269–324. PMID 10835102. Archived from the original on 5 July 2008. Retrieved 24 December 2018.

[pmid_11193811-7] Reubi JC (2000). "In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications". Annals of the New York Academy of Sciences. 921: 1–25. doi:10.1111/j.1749-6632.2000.tb06946.x. PMID 11193811.

[pmid_10850463-8] Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (Jun 2000). "Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin". Cancer Research. 60 (11): 3105–12. PMID 10850463.

[pmid_9543159-9] Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation". The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1299–305. doi:10.1210/jc.83.4.1299. PMID 9543159.

[Knutsson-2002-10] Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport. 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171.

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