CD82

CD82
معین‌کننده‌ها
نام‌های دیگر	CD82, 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27, CD82 molecule
شناسه‌های بیرونی	OMIM: 600623 MGI: 104651 HomoloGene: 20512 GeneCards: CD82
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	93,293,485 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی;
ترکیبات سلولی	• integral component of membrane; • پوسته یاخته; • integral component of plasma membrane; • extracellular exosome; • membrane;
فرایند زیستی	• cell surface receptor signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3732
	12521
	ENSG00000085117
	ENSMUSG00000027215
	P27701
	P40237
	NM_001024844، NM_002231، XM_006718223 XM_011520067، NM_001024844، NM_002231، XM_006718223
	NM_001271430، NM_001271431، NM_001271432، NM_001271461، NM_001271462، NM_007656 NM_001136055، NM_001271430، NM_001271431، NM_001271432، NM_001271461، NM_001271462، NM_007656
	NP_002222، XP_006718286، XP_011518369 NP_001020015، NP_002222، XP_006718286، XP_011518369
	NP_001258359، NP_001258360، NP_001258361، NP_001258390، NP_001258391، NP_031682 NP_001129527، NP_001258359، NP_001258360، NP_001258361، NP_001258390، NP_001258391، NP_031682
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

مجموعه تمایزی ۸۲ (به انگلیسی: CD82) یک پروتئین است که در انسان توسط ژن «CD82» کُدگذاری می‌شود.^[۴]

این ژن سرکوب‌کنندهٔ متاستاز، یک گلیکوپروتئین پوسته‌ای است که ساخت آن در تومورهای پیشرفت‌کننده کاهش یافته‌است و بیانِ آن با ژن پی۵۳ مرتبط است و توسط آن تحریک می‌شود.

پروتئین CD82 با مولکول‌های CD19،^[۵]^[۶] CD63^[۷] و CD234^[۸] تعامل پروتئین-پروتئین دارد.

این پروتئین نقش مهمی در ایجاد آندومتریوز ایفا می‌کند.^[۹]

جستارهای وابسته

مجموعه تمایزی

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027215 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CD82 CD82 molecule".
↑ Imai T, Kakizaki M, Nishimura M, Yoshie O (August 1995). "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". Journal of Immunology. 155 (3): 1229–39. PMID 7636191.
↑ Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry. 273 (46): 30537–43. doi:10.1074/jbc.273.46.30537. PMID 9804823.
↑ Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology. 161 (7): 3282–91. PMID 9759843.
↑ Hur J, Choi JI, Lee H, Nham P, Kim TW, Chae CW, et al. (April 2016). "CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages". Cell Stem Cell. 18 (4): 508–21. doi:10.1016/j.stem.2016.01.013. PMID 26996598.
↑ Timologou, A; Zafrakas M; Grimbizis G; Miliaras D; Kotronis K; Stamatopoulos P; Tarlatzis B (February 2016). "Immunohistochemical expression pattern of metastasis suppressors". European Journal of Obstetrics & Gynecology and Reproductive Biology. 199: 110–115. doi:10.1016/j.ejogrb.2016.02.004. PMID 26918694.

مشارکت‌کنندگان ویکی‌پدیا. «CD82 (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی.

برای مطالعهٔ بیشتر

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Ichikawa T, Ichikawa Y, Dong J, Hawkins AL, Griffin CA, Isaacs WB, et al. (June 1992). "Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11". Cancer Research. 52 (12): 3486–90. PMID 1596907.
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Dong JT, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barrett JC (May 1995). "KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2". Science. 268 (5212): 884–6. Bibcode:1995Sci...268..884D. doi:10.1126/science.7754374. PMID 7754374.
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Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME (September 1996). "Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". Journal of Immunology. 157 (5): 2039–47. PMID 8757325.
Szöllósi J, Horejsí V, Bene L, Angelisová P, Damjanovich S (October 1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY". Journal of Immunology. 157 (7): 2939–46. PMID 8816400.
Dong JT, Isaacs WB, Barrett JC, Isaacs JT (April 1997). "Genomic organization of the human KAI1 metastasis-suppressor gene". Genomics. 41 (1): 25–32. doi:10.1006/geno.1997.4618. PMID 9126478.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology. 161 (7): 3282–91. PMID 9759843.
Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry. 273 (46): 30537–43. doi:10.1074/jbc.273.46.30537. PMID 9804823.
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 ( Pt 1) (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
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Shibagaki N, Hanada K, Yamashita H, Shimada S, Hamada H (December 1999). "Overexpression of CD82 on human T cells enhances LFA-1 / ICAM-1-mediated cell-cell adhesion: functional association between CD82 and LFA-1 in T cell activation". European Journal of Immunology. 29 (12): 4081–91. doi:10.1002/(SICI)1521-4141(199912)29:12<4081::AID-IMMU4081>3.0.CO;2-I. PMID 10602019.
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پیوند به بیرون

CD82 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم CD82 انسانی و صفحهٔ جزئیات ژنی CD82 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027215 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: CD82 CD82 molecule".

[pmid7636191-5] Imai T, Kakizaki M, Nishimura M, Yoshie O (August 1995). "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". Journal of Immunology. 155 (3): 1229–39. PMID 7636191.

[pmid9804823-6] Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry. 273 (46): 30537–43. doi:10.1074/jbc.273.46.30537. PMID 9804823.

[pmid9759843-7] Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology. 161 (7): 3282–91. PMID 9759843.

[8] Hur J, Choi JI, Lee H, Nham P, Kim TW, Chae CW, et al. (April 2016). "CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages". Cell Stem Cell. 18 (4): 508–21. doi:10.1016/j.stem.2016.01.013. PMID 26996598.

[9] Timologou, A; Zafrakas M; Grimbizis G; Miliaras D; Kotronis K; Stamatopoulos P; Tarlatzis B (February 2016). "Immunohistochemical expression pattern of metastasis suppressors". European Journal of Obstetrics & Gynecology and Reproductive Biology. 199: 110–115. doi:10.1016/j.ejogrb.2016.02.004. PMID 26918694.

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پروتئین‌های غشایی (بجز گیرنده سطح سلولی، آنزیم‌ها و اسکلت سلولی)
ارستین	SAG ARRB1 ARRB2 ARR3
پوشاننده‌ی غشای 4A	CD20 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
میلین	پروتئین اصلی میلین PMP2 پروتئین پروتئولیپید میلین پروتئین پروتئولیپید ۱ Myelin oligodendrocyte glycoprotein گلیکوپروتئین شبه میلین Myelin protein zero
سورفکتانت ریوی	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
تترا اسپنین	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 CD82 CD81 TSPAN29 CD63 TSPAN31 TSPAN32 TSPAN33 TSPAN34
سایر/گروه‌بندی‌نشده	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
همچنین ببینید: سایر اختلالات پروتئین‌های غشای سلولی