CYP2B6

CYP2B6
ساختارهای موجود
PDBجستجوی هم‌ساخت‌شناسی: PDBe RCSB
معین‌کننده‌ها
نام‌های دیگرCYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450, cytochrome P450 family 2 subfamily B member 6, Cytochrome P450 2B6
شناسه‌های بیرونیOMIM: 123930 MGI: 88598 HomoloGene: 73894 GeneCards: CYP2B6
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

1555

13088

آنسامبل

ENSG00000197408

ENSMUSG00000030483

یونی‌پروت

P20813

P12791

RefSeq (mRNA)

NM_000767

NM_009999

RefSeq (پروتئین)

NP_000758

ن/م

موقعیت (UCSC)ن/مChr : 25.6 – 25.63 Mb
جستجوی PubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

سیتوکروم P450 2B6 آنزیمی است که در انسان توسط ژن CYP2B6 کدگذاری می‌شود.[۴] CYP2B6 عضوی از گروه آنزیم‌های سیتوکروم پی ۴۵۰ است و همراه با CYP2A6 و همراه با بسیاری از مواد دیگر در متابولیسم نیکوتین نقش دارد.[۴]

لیگاندها

بسترهامهارکننده‌هاالقاکننده‌ها
قوی:

متوسط:

قدرت نامشخص

منابع

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030483 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. 1 2 "Entrez Gene: cytochrome P450".
  5. 1 2 3 4 5 6 7 8 9 10 11 12 13 Swedish environmental classification of pharmaceuticals - دارونامه - Facts for prescribers (Fakta för förskrivare). Retrieved July 2011
  6. 1 2 3 4 5 6 7 8 9 10 11 Flockhart DA (2007). "Drug Interactions: Cytochrome P450 Drug Interaction Table". Indiana University School of Medicine. Archived from the original on 10 اكتبر 2007. Retrieved 4 September 2022. {{cite web}}: Check date values in: |archive-date= (help) Retrieved on December 25, 2008.
  7. ↑ Alkattan, A. , & Alsalameen, E. (2021). Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment. Expert opinion on drug metabolism & toxicology, 10.1080/17425255.2021.1925249. Advance online publication. https://doi.org/10.1080/17425255.2021.1925249
  8. ↑ Rao LK, Flaker AM, Friedel CC, Kharasch ED (December 2016). "Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance". Anesthesiology. 125 (6): 1103–1112. doi:10.1097/ALN.0000000000001392. PMID 27763887. S2CID 41380105.
  9. ↑ Meyer MR, Bach M, Welter J, Bovens M, Turcant A, Maurer HH (July 2013). "Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn". Analytical and Bioanalytical Chemistry. 405 (19): 6307–21. doi:10.1007/s00216-013-7051-6. PMID 23774830. S2CID 27966043.
  10. 1 2 3 4 5 6 Walsky RL, Astuccio AV, Obach RS (December 2006). "Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6". Journal of Clinical Pharmacology. 46 (12): 1426–38. doi:10.1177/0091270006293753. PMID 17101742. S2CID 40915941.
  11. ↑ Obach RS, Cox LM, Tremaine LM (February 2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metabolism and Disposition. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID 15547048. S2CID 7254643.
  12. ↑ Ekins S, Iyer M, Krasowski MD, Kharasch ED (June 2008). "Molecular characterization of CYP2B6 substrates". Current Drug Metabolism. 9 (5): 363–73. doi:10.2174/138920008784746346. PMC 2426921. PMID 18537573.
  13. ↑ Phillips BG, Gandhi AJ, Sanoski CA, Just VL, Bauman JL (1997). "Comparison of intravenous diltiazem and verapamil for the acute treatment of atrial fibrillation and atrial flutter". Pharmacotherapy. 17 (6): 1238–45. PMID 9399606.
  14. ↑ Guo Z, Raeissi S, White RB, Stevens JC (March 1997). "Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes". Drug Metabolism and Disposition. 25 (3): 390–3. PMID 9172960.
  15. ↑ Sridar, C.; Kenaan, C.; Hollenberg, P. F. (2012). "Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts". Drug Metabolism and Disposition: The Biological Fate of Chemicals. 40 (12): 2256–2266. doi:10.1124/dmd.112.046979. PMC 3500550. PMID 22936314.
  16. ↑ Volak LP, Ghirmai S, Cashman JR, Court MH (August 2008). "Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor". Drug Metabolism and Disposition. 36 (8): 1594–605. doi:10.1124/dmd.108.020552. PMC 2574793. PMID 18480186.
  17. ↑ Appiah-Opong R, Commandeur JN, van Vugt-Lussenburg B, Vermeulen NP (June 2007). "Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products". Toxicology. 235 (1–2): 83–91. doi:10.1016/j.tox.2007.03.007. PMID 17433521.
  18. 1 2 3 4 5 Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ (October 2000). "CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants". Drug Metabolism and Disposition. 28 (10): 1176–83. PMID 10997936.
  19. ↑ Makino KM, Porsteinsson AP (June 2011). "Memantine: a treatment for Alzheimer's disease with a new formulation". Aging Health. 7 (3): 349–62. doi:10.2217/ahe.11.31.
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