IRF4

IRF4
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2DLL
معین‌کننده‌ها
نام‌های دیگر	IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4
شناسه‌های بیرونی	OMIM: 601900 MGI: 1096873 HomoloGene: 1842 GeneCards: IRF4
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۳ (موش)
پایان	30,950,959 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• sequence-specific DNA binding; • DNA binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • protein-lysine N-methyltransferase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
ترکیبات سلولی	• سیتوزول; • membrane; • نوکلئوپلاسم; • هسته یاخته;
فرایند زیستی	• GO:0009373 regulation of transcription, DNA-templated; • interferon-gamma-mediated signaling pathway; • regulation of T-helper cell differentiation; • myeloid dendritic cell differentiation; • transcription, DNA-templated; • T-helper 17 cell lineage commitment; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • peptidyl-lysine methylation; • negative regulation of toll-like receptor signaling pathway; • type I interferon signaling pathway; • histone H3 acetylation; • histone H4 acetylation; • positive regulation of DNA binding; • T cell activation; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • defense response to protozoan; • protein methylation; • transcription by RNA polymerase II; • cytokine-mediated signaling pathway; • positive regulation of cold-induced thermogenesis; • immune system process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3662
	16364
	ENSG00000137265
	ENSMUSG00000021356
	Q15306
	Q64287
	NM_001195286، NM_002460، NR_036585، NR_046000، XM_047418730 XM_006715090، NM_001195286، NM_002460، NR_036585، NR_046000، XM_047418730
	NM_001347508، XM_036157859، XM_036157860 NM_013674، NM_001347508، XM_036157859، XM_036157860
	NP_002451، XP_006715153 NP_001182215، NP_002451، XP_006715153
	NP_038702، XP_036013752، XP_036013753 NP_001334437، NP_038702، XP_036013752، XP_036013753
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فاکتور تنظیم‌کننده شمارهٔ ۴ اینترفرون (انگلیسی: Interferon regulatory factor 4) که با نام «MUM1» هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «IRF4» کُدگذاری می‌شود^[۴]^[۵]^[۶] که بر روی بازوی کوتاه کروموزوم ۶ واقع شده‌است.

در ملانوسیت‌ها ژن IRF4 احتمالاً توسط MITF تنظیم می‌شود.^[۷] این ژن یک فاکتور رونویسی است که احتمالاً در انواع حاد سرطان خون دخیل است.^[۸] ژن IRF4 به‌شدت در تولید رنگدانه مؤثر است: حسایت پوست به نور خورشید، کک‌ومک، چشمان آبی و رنگ قهوه‌ای موها همگی با این ژن در ارتباط هستند.^[۹] یک واریان دیگر از این ژن در سفیدشدن موها نقش دارد.^[۱۰]

جستارهای وابسته

HTRA2

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021356 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Grossman A, Mittrücker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics. 37 (2): 229–33. doi:10.1006/geno.1996.0547. PMID 8921401.
↑ Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L (Jun 2008). "Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes". J Virol. 82 (13): 6251–8. doi:10.1128/JVI.00163-08. PMC 2447047. PMID 18417578.
↑ "Entrez Gene: IRF4 interferon regulatory factor 4".
↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
↑ Adamaki M, Lambrou GI, Athanasiadou A, Tzanoudaki M, Vlahopoulos S, Moschovi M (2013). "Implication of IRF4 aberrant gene expression in the acute leukemias of childhood". PLoS ONE. 8 (8): e72326. doi:10.1371/journal.pone.0072326. PMC 3744475. PMID 23977280.
↑ Praetorius C, Grill C, Stacey SN, Metcalf AM, Gorkin DU, Robinson KC, et al. (November 2013). "A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway". Cell. 155 (5): 1022–33. doi:10.1016/j.cell.2013.10.022. PMC 3873608. PMID 24267888.
↑ Adhikari K, Fontanil T, Cal S, Mendoza-Revilla J, Fuentes-Guajardo M, Chacón-Duque JC, et al. (2016). "A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features". Nature Communications. 7: 10815. doi:10.1038/ncomms10815. PMC 4773514. PMID 26926045. {{cite journal}}: Unknown parameter |laysource= ignored (help); Unknown parameter |laysummary= ignored (help)

Mamane Y, Sharma S, Grandvaux N, Hernandez E, Hiscott J (2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis". J. Interferon Cytokine Res. 22 (1): 135–43. doi:10.1089/107999002753452746. PMID 11846984.
Yamagata T, Nishida J, Tanaka S, Sakai R, Mitani K, Yoshida M, Taniguchi T, Yazaki Y, Hirai H (1996). "A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes". Mol. Cell. Biol. 16 (4): 1283–94. PMC 231112. PMID 8657101.
Iida S, Rao PH, Butler M, Corradini P, Boccadoro M, Klein B, Chaganti RS, Dalla-Favera R (1997). "Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma". Nat. Genet. 17 (2): 226–30. doi:10.1038/ng1097-226. PMID 9326949.
Brass AL, Zhu AQ, Singh H (1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMC 1171190. PMID 10022840.
Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1". J. Biol. Chem. 274 (16): 11115–24. doi:10.1074/jbc.274.16.11115. PMID 10196196.
Marecki S, Atchison ML, Fenton MJ (1999). "Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages". J. Immunol. 163 (5): 2713–22. PMID 10453013.
Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. PMC 2195723. PMID 10601358.
Mamane Y, Sharma S, Petropoulos L, Lin R, Hiscott J (2000). "Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52". Immunity. 12 (2): 129–40. doi:10.1016/S1074-7613(00)80166-1. PMID 10714679.
Gupta S, Anthony A, Pernis AB (2001). "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins". J. Immunol. 166 (10): 6104–11. doi:10.4049/jimmunol.166.10.6104. PMID 11342629.
Imaizumi Y, Kohno T, Yamada Y, Ikeda S, Tanaka Y, Tomonaga M, Matsuyama T (2002). "Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia". Jpn. J. Cancer Res. 92 (12): 1284–92. doi:10.1111/j.1349-7006.2001.tb02151.x. PMID 11749693.
Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH (2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". J. Exp. Med. 195 (8): 1003–12. doi:10.1084/jem.20011128. PMC 2193700. PMID 11956291.
Sharma S, Grandvaux N, Mamane Y, Genin P, Azimi N, Waldmann T, Hiscott J (2002). "Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells". J. Immunol. 169 (6): 3120–30. doi:10.4049/jimmunol.169.6.3120. PMID 12218129.
Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK (2003). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. 139 (1): 55–9. doi:10.1016/S1047-8477(02)00514-2. PMID 12372320.
Hu CM, Jang SY, Fanzo JC, Pernis AB (2003). "Modulation of T cell cytokine production by interferon regulatory factor-4". J. Biol. Chem. 277 (51): 49238–46. doi:10.1074/jbc.M205895200. PMID 12374808.
Fanzo JC, Hu CM, Jang SY, Pernis AB (2003). "Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4)". J. Exp. Med. 197 (3): 303–14. doi:10.1084/jem.20020717. PMC 2193834. PMID 12566414.
O'Reilly D, Quinn CM, El-Shanawany T, Gordon S, Greaves DR (2003). "Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner". J. Biol. Chem. 278 (24): 21909–19. doi:10.1074/jbc.M212150200. PMID 12676954.
Sundram U, Harvell JD, Rouse RV, Natkunam Y (2004). "Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA". Mod. Pathol. 16 (8): 802–10. doi:10.1097/01.MP.0000081726.49886.CF. PMID 12920225.

پیوند به بیرون

IRF4 در دانشنامهٔ اجزای دی‌ان‌ای

IRF4 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

منابع

مشارکت‌کنندگان ویکی‌پدیا. «IRF4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۸ فوریه ۲۰۱۸.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021356 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_8921401-4] Grossman A, Mittrücker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics. 37 (2): 229–33. doi:10.1006/geno.1996.0547. PMID 8921401.

[pmid_18417578-5] Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L (Jun 2008). "Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes". J Virol. 82 (13): 6251–8. doi:10.1128/JVI.00163-08. PMC 2447047. PMID 18417578.

[entrez-6] "Entrez Gene: IRF4 interferon regulatory factor 4".

[pmid_19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

[pmid_23977280-8] Adamaki M, Lambrou GI, Athanasiadou A, Tzanoudaki M, Vlahopoulos S, Moschovi M (2013). "Implication of IRF4 aberrant gene expression in the acute leukemias of childhood". PLoS ONE. 8 (8): e72326. doi:10.1371/journal.pone.0072326. PMC 3744475. PMID 23977280.

[pmid_24267888-9] Praetorius C, Grill C, Stacey SN, Metcalf AM, Gorkin DU, Robinson KC, et al. (November 2013). "A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway". Cell. 155 (5): 1022–33. doi:10.1016/j.cell.2013.10.022. PMC 3873608. PMID 24267888.

[pmid_26926045-10] Adhikari K, Fontanil T, Cal S, Mendoza-Revilla J, Fuentes-Guajardo M, Chacón-Duque JC, et al. (2016). "A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features". Nature Communications. 7: 10815. doi:10.1038/ncomms10815. PMC 4773514. PMID 26926045. {{cite journal}}: Unknown parameter |laysource= ignored (help); Unknown parameter |laysummary= ignored (help)

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