SMAD2

SMAD2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1DEV, 1KHX, 1U7V, 2LB3
معین‌کننده‌ها
نام‌های دیگر	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2, LDS6, CHTD8
شناسه‌های بیرونی	OMIM: 601366 MGI: 108051 HomoloGene: 21197 GeneCards: SMAD2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۸ (موش)
پایان	76,444,034 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• phosphatase binding; • I-SMAD binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • R-SMAD binding; • co-SMAD binding; • transcription factor binding; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • transforming growth factor beta receptor binding; • type I transforming growth factor beta receptor binding; • protein homodimerization activity; • chromatin binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • double-stranded DNA binding; • SMAD binding; • DNA binding; • protein heterodimerization activity; • ubiquitin protein ligase binding; • primary miRNA binding; • disordered domain specific binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • tau protein binding;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • هسته یاخته; • heteromeric SMAD protein complex; • SMAD protein complex; • transcription regulator complex; • intracellular anatomical structure; • نوکلئوپلاسم; • activin responsive factor complex; • GO:0009327 protein-containing complex;
فرایند زیستی	• pattern specification process; • ureteric bud development; • endoderm development; • response to cholesterol; • organ growth; • embryonic pattern specification; • zygotic specification of dorsal/ventral axis; • post-embryonic development; • protein phosphorylation; • pericardium development; • regulation of binding; • transforming growth factor beta receptor signaling pathway; • negative regulation of cell population proliferation; • cell fate commitment; • common-partner SMAD protein phosphorylation; • GO:0009373 regulation of transcription, DNA-templated; • SMAD protein signal transduction; • lung development; • signal transduction involved in regulation of gene expression; • insulin secretion; • in utero embryonic development; • negative regulation of transforming growth factor beta receptor signaling pathway; • negative regulation of gene expression; • nodal signaling pathway; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • development of the heart; • pancreas development; • endoderm formation; • activin receptor signaling pathway; • SMAD protein complex assembly; • positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; • embryonic foregut morphogenesis; • GO:1901227 negative regulation of transcription by RNA polymerase II; • response to glucose; • positive regulation of epithelial to mesenchymal transition; • developmental growth; • لایه‌زایی; • GO:1990744، GO:1990729 primary miRNA processing; • positive regulation of BMP signaling pathway; • embryonic cranial skeleton morphogenesis; • GO:0045996 negative regulation of transcription, DNA-templated; • paraxial mesoderm morphogenesis; • GO:0007243 intracellular signal transduction; • somatic stem cell population maintenance; • mesoderm formation; • regulation of transforming growth factor beta receptor signaling pathway; • GO:1901313 positive regulation of gene expression; • anterior/posterior pattern specification; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • transcription by RNA polymerase II; • protein deubiquitination; • بهبود زخم; • adrenal gland development; • secondary palate development;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4087
	17126
	ENSG00000175387
	ENSMUSG00000024563
	Q15796
	Q62432
	NM_001135937، NM_005901، XM_017025749، XM_047437507، XM_047437508 NM_001003652، NM_001135937، NM_005901، XM_017025749، XM_047437507، XM_047437508
	NM_010754، XM_006525699، NM_001311070، XM_017317842، XM_030250351 NM_001252481، NM_010754، XM_006525699، NM_001311070، XM_017317842، XM_030250351
	NP_001129409، NP_005892، XP_005258316، XP_006722514، XP_011524286، XP_011524287، XP_016881234، XP_016881235، XP_016881236، XP_016881237، XP_016881238، XP_016881239، XP_024306941 NP_001003652، NP_001129409، NP_005892، XP_005258316، XP_006722514، XP_011524286، XP_011524287، XP_016881234، XP_016881235، XP_016881236، XP_016881237، XP_016881238، XP_016881239، XP_024306941
	NP_001297999، NP_034884، XP_006525762، XP_017173331، XP_030106211 NP_001239410، NP_001297999، NP_034884، XP_006525762، XP_017173331، XP_030106211
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

هم‌ساخت ۲ مادران مخالف دکپنتاپلجیک (انگلیسی: Mothers against decapentaplegic homolog 2) یک پروتئین است که در انسان توسط ژن «SMAD2» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین عضوی از خانواده بزرگ SMAD است که این نیز به نوبهٔ خود، جزئی از اَبَرخانوادهٔ فاکتور رشد تغییردهنده بتا است.

پروتئین SMAD2 در پیام‌رسانی سلولی و ساماندهی بیان ژن نقش دارد.

این پروتئین همچنین با مولکول SMAD3^[۶]^[۷] تعامل پروتئین-پروتئین دارد.

جستارهای وابسته

مادران مخالف دکپنتاپلجیک

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024563 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L (August 1996). "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma". Cell. 86 (4): 543–52. doi:10.1016/S0092-8674(00)80128-2. PMID 8752209.
↑ Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135.
↑ Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P (September 1997). "TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4". EMBO J. 16 (17): 5353–62. doi:10.1093/emboj/16.17.5353. ISSN 0261-4189. PMC 1170167. PMID 9311995.
↑ Lebrun JJ, Takabe K, Chen Y, Vale W (January 1999). "Roles of pathway-specific and inhibitory Smads in activin receptor signaling". Mol. Endocrinol. 13 (1): 15–23. doi:10.1210/mend.13.1.0218. ISSN 0888-8809. PMID 9892009.

مشارکت‌کنندگان ویکی‌پدیا. «Mothers against decapentaplegic homolog 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۳ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

Wrana JL (1998). "TGF-beta receptors and signalling mechanisms". Mineral and Electrolyte Metabolism. 24 (2–3): 120–30. doi:10.1159/000057359. PMID 9525694.
Massagué J (1998). "TGF-beta signal transduction". Annu. Rev. Biochem. 67: 753–91. doi:10.1146/annurev.biochem.67.1.753. PMID 9759503.
Verschueren K, Huylebroeck D (2000). "Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells". Cytokine Growth Factor Rev. 10 (3–4): 187–99. doi:10.1016/S1359-6101(99)00012-X. PMID 10647776.
Wrana JL, Attisano L (2000). "The Smad pathway". Cytokine Growth Factor Rev. 11 (1–2): 5–13. doi:10.1016/S1359-6101(99)00024-6. PMID 10708948.
Miyazono K (2000). "TGF-beta signaling by Smad proteins". Cytokine Growth Factor Rev. 11 (1–2): 15–22. doi:10.1016/S1359-6101(99)00025-8. PMID 10708949.
Zannis VI, Kan HY, Kritis A, Zanni E, Kardassis D (March 2001). "Transcriptional regulation of the human apolipoprotein genes". Front. Biosci. 6: D456–504. doi:10.2741/Zannis. PMID 11229886.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024563 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8752209-4] Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L (August 1996). "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma". Cell. 86 (4): 543–52. doi:10.1016/S0092-8674(00)80128-2. PMID 8752209.

[pmid8673135-5] Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135.

[pmid9311995-6] Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P (September 1997). "TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4". EMBO J. 16 (17): 5353–62. doi:10.1093/emboj/16.17.5353. ISSN 0261-4189. PMC 1170167. PMID 9311995.

[pmid9892009-7] Lebrun JJ, Takabe K, Chen Y, Vale W (January 1999). "Roles of pathway-specific and inhibitory Smads in activin receptor signaling". Mol. Endocrinol. 13 (1): 15–23. doi:10.1210/mend.13.1.0218. ISSN 0888-8809. PMID 9892009.

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